Efimov Ilia «1,3-Dipolar cycloaddition of а-metalated isocyanides to enamines and enaminones: direct and convenient approach to 1H-2,4-disubstituted pyrroles»
Efimov Ilia «1,3-Dipolar cycloaddition of а-metalated isocyanides to enamines and enaminones: direct and convenient approach to 1H-2,4-disubstituted pyrroles»
2019 The event passed
17 Sep
Location
Moscow, Ordzhonikidze st., 3, room 208
Contact person
Knyazeva Elena
About the event

A novel synthetic strategy based on 1,3-dipolar cycloaddition of a-metalated isocyanides to double bond of different enamines and enaminones represent a direct, simple and effective approach to 2,4-substituted pyrroles from common and commercial available starting materials. We found that potassium tert-butoxide is a unique base which can be used for this type of cycloaddition. The new pyrroles were formed in good-to-excellent yields.

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