Events

With the participation of the faculty of the Institute of Environmental Engineering, as well as students, existing systems of land use models at the global and national levels will be discussed.

The lecture will focus on current issues concerning general trends of translation pedagogy and practice, specificities of translator’s/interpreter’s training, modern approaches to foreign language teaching.

This lecture charts future perspective in the field, while bringing attention to the countless possibilities available by diversifying not only the metal, but also the reactivity modes and tactics to bring peptide functional groups together and produce structurally diverse macrocycles.

This lecture highlights the development of a methodology that provides a repertoire of synthetic tools for the achievement of N-alkylated, macrocyclic peptides, including inhibitors of protein-protein interactions, antibacterial and anticancer peptides. The lecture also reports on the determination of the three-dimensional structures of the macrocyclic peptide serving a mimetics of protein secondary structures. This includes a detailed NMR study (i.e., TOCSY, COSY, HSQC HMBC, and ROESY) combined with molecular dynamic simulation.

In this lecture, we describe novel all-on-resin strategies permitting the synthesis of super potent (nano- and picomolar) tubulysin and dolastatin analogs and their functionalization with cleavable linkers that allow their traceless release after the selective internalization into cancer cells. We also present synthetic methods towards novel targeting peptides and their conjugates to the cytotoxic payloads.