Structural unit: Institute of Medicine.
The Center conducts fundamental and exploratory morphological research with the implementation of its findings in healthcare practice.
Resources
The Resource Center’s laboratory facilities address the needs of priority areas of medical science: oncology, cardiology and angiology, neurology, endocrinology, immunology, pharmacology, reproductive health, regenerative medicine, innovative fundamental technologies in medicine and microbiology.
Equipment Fleet
- Mantra 2 Quantitative Pathology Workstation
- Hardware and software system based on the fully motorized AXIOIMAGER.Z2 research microscope
- JEOL JEM 2100 Analytical Transmission Electron Microscope
- Leica Scanscope Aperio CS2 Microscope Slide Scanner
- Leica ASP 6025 Automatic Closed-Loop Histology Processor
- Leica CM1860UV Cryostat
- KOS High-Speed Multifunctional Histology Processor
- HistoCore AUTOCUT Automated Rotary Microtome
Objectives
- to develop new molecular histology technologies for spatial phenotyping, profiling, and mapping of specific tissue microenvironments with assessment of functional morphology;
- to improve bioinformatic analysis and artificial intelligence technologies for spatial profiling of cells and extracellular structures of the tissue microenvironment, considering intercellular interactions in specific areas;
- to investigate novel mechanisms of remodeling of the fibrous component of connective tissue extracellular involving mast cells.
Partners
- National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
- Research Center of Neurology
- The Federal Center for Neurosurgery (Tyumen)
- Federal Center of Brain Research and Neurotechnologies of the Federal Medical and Biological Agency
- Joint Institute for Nuclear Research
- The National Medical Research Center of Surgery named after A. Vishnevsky
- The Institute of Biomedical Problems
- Research and Clinical Institute for Pediatrics named after Academician Yuri Veltischev of the Ministry of Health of the Russian Federation
- The Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
- Lomonosov Moscow State University
- Voronezh State Medical University named after N.N. Burdenko
- Orenburg State Medical University
Foreign partners
- Hamburg Institute of Hemapathology (Hamburg, Germany)
- Institute of Mitochondrial Biomedicine of Xi’an Jiaotong University
- Belarusian State Medical University (Minsk, Belarus)
- Molecular Hydrogen Institute (Cedar City, USA)
- Fraunhofer Institute for Translational Medicine and Pharmacology (Hamburg, Germany)
- Institute of Allergology of Charité — Berlin University Medicine (Berlin, Germany)
- Mono- and multiplex algorithms for studying the functional morphology of the tissue microenvironment using bioinformatic analysis and artificial intelligence technologies.
- Multidimensional analysis of the morphological landscape of local tissue niches.
- Search for spatiotemporal patterns of cell organization into functional morphogenetic clusters.
- Study of intercellular interaction in normal and pathological conditions.
- Spatial phenotyping, profiling, and mapping of tissue microenvironment components in oncogenesis, inflammation, fibrosis.
The Center’s researchers proposed an original method for detecting immunocompetent cells in the tissue microenvironment. It allows for the development of translational biomarkers for morphological studies and the identification of new mechanisms underlying the development of pathological changes, such as fibrosis, inflammation and tumor growth.
- New patterns in the spatial phenotype of mast cells in the development of skin melanoma were identified.
- Patterns in the protease profile of bone marrow mast cells in patients with systemic mastocytosis were determined.