A RUDN University chemist created anti-tumour compounds that are up to 80 times more effective than their counterparts
Platinum-based anticancer drugs — cisplatin, oxaliplatin, and carboplatin — are used for chemotherapy in about half of cancer cases. They penetrate cells and interact with DNA molecules. The process is fatal for rapidly dividing cancer cells because the drugs prevent the duplication of DNA molecules, which is necessary for successful division. Since cancer cells divide rapidly, they are the first to be affected. Still, platinum derivatives have certain disadvantages: low stability under physiological conditions and high toxicity.
To create new drugs, a strategy that involves the development of hybrid molecules is often used in modern chemistry. Such substances consist of two or more active fragments that are linked by a linker into one molecule. They usually have a double action, characteristic of each of the fragments.
A chemist from RUDN University, candidate of biological sciences Kirill Kirsanov, created a series of new drugs: hybrids of cisplatin, lonidamine, and bexarotene. Lonidamine itself has an anti-tumour effect due to its ability to suppress energy metabolism in cancer cells. In combination with radiation therapy, it is used to treat brain tumours. Bexarotene is used for the treatment of lung cancer and breast cancer, as it inhibits the growth of tumour cells of hematopoietic and squamous origin.
A derivative of cisplatin with bexarotene turned out to be the most promising. A combination of succinic acid and ethylenediamine was used as a linker. In tests conducted on four tumour cell lines, the hybrid drug was 80 times more active than bexaroten and 20 times higher on average than cisplatin, and the new drug was 80 times more active than cisplatin on MCF7D cell line. Based on the resulting leading compound, new and more effective anti-tumour medications can be developed.
The paper was published in the journal Inorganica Chimica Acta
The project to develop a cellular model of the placenta became the winner in the Scientific Materials category of the Young Scientists 3.0 competition, organized with the support of the Presidential Grants Foundation and T-Bank.
Ten scientific journals published by RUDN University have been included in the highest level of the state list of scientific publications, the White List.
Forests are not only the lungs of the planet, but also home to millions of species. However, it has remained unclear how underground interactions between trees and fungi affect forest species richness in different climatic conditions. Previous studies have yielded conflicting results: in some regions, the dominance of certain fungi reduced tree diversity, while in others it increased it.
The project to develop a cellular model of the placenta became the winner in the Scientific Materials category of the Young Scientists 3.0 competition, organized with the support of the Presidential Grants Foundation and T-Bank.
Ten scientific journals published by RUDN University have been included in the highest level of the state list of scientific publications, the White List.
Forests are not only the lungs of the planet, but also home to millions of species. However, it has remained unclear how underground interactions between trees and fungi affect forest species richness in different climatic conditions. Previous studies have yielded conflicting results: in some regions, the dominance of certain fungi reduced tree diversity, while in others it increased it.