RUDN scientists have created new substances to fight resistant bacteria
Biofilms are a bacterial “shield” that makes them almost invulnerable to drugs and immunity. Because of them, infections become chronic and difficult to treat. The new substances will help in the fight against such dangerous bacteria as E. Coli, Pseudomonas aeruginosa and Staphylococcus aureus.
“As a basis we took already known compounds - 5-aryl-2-aminoimidazoles. To them we added an amino group. This change allowed us to obtain compounds with improved ability to inhibit the formation of biofilms. We created a library of new derivatives with different substituents including halogens and alkyl chains. Their activity was tested on biological models and potential toxicity was assessed on human cell lines, immune cells and a nematode model (Caenorhabditis elegans),” - Erik Van der Eyken, Director of the Scientific Center for Microwave-assisted Organic Synthesis at RUDN.
The project to develop a cellular model of the placenta became the winner in the Scientific Materials category of the Young Scientists 3.0 competition, organized with the support of the Presidential Grants Foundation and T-Bank.
Ten scientific journals published by RUDN University have been included in the highest level of the state list of scientific publications, the White List.
Forests are not only the lungs of the planet, but also home to millions of species. However, it has remained unclear how underground interactions between trees and fungi affect forest species richness in different climatic conditions. Previous studies have yielded conflicting results: in some regions, the dominance of certain fungi reduced tree diversity, while in others it increased it.
The project to develop a cellular model of the placenta became the winner in the Scientific Materials category of the Young Scientists 3.0 competition, organized with the support of the Presidential Grants Foundation and T-Bank.
Ten scientific journals published by RUDN University have been included in the highest level of the state list of scientific publications, the White List.
Forests are not only the lungs of the planet, but also home to millions of species. However, it has remained unclear how underground interactions between trees and fungi affect forest species richness in different climatic conditions. Previous studies have yielded conflicting results: in some regions, the dominance of certain fungi reduced tree diversity, while in others it increased it.