Fundamental Medicine

Molecular mechanisms of carcinogenesis and its intracellular regulation system. Search for agents with antitumor activity

Studies of the molecular basis of tumour growth mechanisms and the system of its intracellular regulation, as well as the creation of drugs with antitumor activity and effective diagnostics of breast cancer. The objectives of the study include: a) obtaining data on the spectrum of human tumour lines that are sensitive to the action of L-lysine α oxidase, which is important for the development of pharmaceutical articles on the substance of this enzyme when administered parenterally; 6) study of the redox-dependent mechanism of regulation of the development of drug resistance of tumor cells; в) study of tissue and serum biological markers to effectively predict the clinical course of breast cancer. The obtained results are supposed to be used to create a new anticancer drug based on the enzyme L-lysine α oxidase; creating a fundamental framework that takes into account the redox-dependent regulation of cellular processes for new schemes of effective combination chemotherapy; creating new methods for diagnosing and monitoring the effectiveness of breast cancer therapy.

Features of metal-ligand homeostasis in metabolic syndrome and its individual components

The study of the features of the exchange of macro-and micronutrients in patients with metabolic syndrome and its components. At the stages of the study, a statistical analysis was carried out to determine the differences in the analyzed parameters between the observation and control groups, the relationships between the level of macro- and microelements in bio-indicator substrates, as well as markers of lipid and carbohydrate metabolism disorders. Such approach allows to reveal complex violations of exchange of macro-and microelements in an organism in the conditions of development of metabolic syndrome, and also to define the character of interrelations between separate toxic and essential chemical elements that at the moment of the development of the corresponding direction of science is practically not studied. Moreover, on the basis of the obtained data, the most pronounced changes in metal-ligand homeostasis in metabolic syndrome and its components were established, which is possible only with the use of the proposed integrated approach. The identification of critical changes in the macro-and microelement status of the body during metabolic syndrome will allow the data obtained to be used in the development of tools for metabolic correction (drugs and dietary supplements).