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ORDER BY num ASC LIMIT 1' at line 3Array
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[name] => Development of new methods for synthesis of natural compounds and its analogues on a basis of domino-reactions and highly selective reagents to search for new biologically active substances
[seo_title] => Development of new methods for synthesis of natural compounds and its analogues on a basis of domino-reactions and highly selective reagents to search for new biologically active substances
[seo_keywords] => Development of new methods for synthesis of natural compounds and its analogues on a basis of domino-reactions and highly selective reagents to search for new biologically active substances
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[0] => in hematology (treatment of blood clotting disorders, treatment of hematologica malignancy, treatment of hemoglobinopathy and genetical bleeding diathesis; hemophilia).
[1] => in osteology (treatment and prevention of bone marrow diseases);
[2] => immunohematology (study and subsequent detection of humoral immunity factors and antigenic specificity of blood)
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[0] => Study of reaction mechanisms, thermodynamic / kinetic control of reversible processes.
[1] => Usage of received data in education courses (chemistry of heterocyclic compounds, pharmaceutical testing, medical chemistry).
[2] => Separately, we should mention the biological screening we are planning on the unique equipment of the Common Use Center (CUS) of the Faculty of Physical, Mathematical and Natural Sciences of RUDN (Plate reader Infinite-1000). The series of compounds obtained for this project will be subjected to biological activity tests, and the results obtained, after their analysis (by using appropriate software), will outline ways for the further modification of basic structures (hit-to-lead) and the next step will be to assess the toxicity assessment and in vivo bioactivity of drug candidates.
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The results of the one-year project will include the development of effective approaches to obtain practically useful substances, mostly with the help of new, original transformations. This will significantly expand our knowledge in the chemistry of indoles, furan and chroman and will also make a wide range of new heterocycles for biological screening available. The proposed approaches to target the compounds and other results conform to international standards and even exceed them in a number of positions.
[1] =>
The practical use of bio-test results and their licensing for further commercialization will become available due to the availability of unique equipment.
[2] =>
The obtained results (both fundamental and applied) are used in the educational process in the framework of current and new courses.
[3] =>
30 articles will be published in journals included in the WoS and Scopus databases and an application for 1 patent will be filed based on the project results
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