Anton Syroeshkin

Research and Innovation

RUDN Scientists

Anton Syroeshkin

Doctor of Biological Sciences

Professor, Head of the Department of Pharmaceutical and Toxicological Chemistry ,

“Radioactive elements are inevitable for life, since their number is a characteristic species feature, but they are not included in the chemical compounds of the bodies of organisms, but are a source of energy for living substance” V. I. Vernadsky

+7 (495) 434-70-01

syroeshkin-av@rudn.ru

Contact a scientist

Scientific interests:

pharmaceutical substance laser diffraction kinetic isotope effect excipient

1991

Graduated from Lomonosov Moscow State University, the Biological Faculty, Speciality - “Biochemistry”.

1991 - 1997

Researcher of Lomonosov Moscow State University.

1996

Candidate thesis on “Kinetic mechanism of ATP hydrolysis reaction catalyzed by mitochondrial F1FO-ATP” was defended, speciality “Biochemistry”. Academic degree - Candidate of Biological Sciences was awarded.

1998 - 2012

Head of the laboratory of Analytical Chemistry, State Oceanography Institute.

2001 - 2007

Associate professor, professor of the Department of Pharmaceutical and Toxicological Chemistry of the Medical Faculty RUDN University.

2002

Doctoral thesis on “Kinetics of cellular processes in norm and pathology” was defended, specialty “Systemic analysis”. Academic degree - Doctor of Biological Sciences was awarded.

2005 - 2009

Member of the Expert Council of the Russian Foundation for Basic Research (RFBR) on Earth Sciences.

2006

The academic title of Professor of the Department of Pharmaceutical and Toxicological Chemistry was awarded.

2007 - 2012

Head of the Department of Biology and General Genetics of the Medical Faculty RUDN University.

2010 - 2014

Deputy director for scientific work of E. K. Fedorov Institute of Applied Geophysics.

2010 - 2014

Member of the Board of chief constructors of Roscosmos for the space complexes “Electro”, “Meteor” and “Ionozond”.

2015

Full member of the Russian Academy of Natural Sciences (RANS), the Department “Monitoring of high-energy processes”.

2015 - present

Head of the Department of Pharmaceutical and Toxicological Chemistry, the Institute of Medicine RUDN University.

2018 - present

Chairman of the permanent Dissertation Council 0300.001. specialties: 14.04.02 - Pharmaceutical Chemistry, Pharmacognosy (Pharmaceutical Sciences); 14.03.06 - Pharmacology, Clinical Pharmacology (Pharmaceutical Sciences) RUDN University.

Teaching

Conducts lectures to RUDN students, specialty - “Pharmacy” and postgraduate students, direction “Pharmacy”:

“Ecological toxicology”,
“Elemental analysis”.

The author of the following course-books and study guides:

Pharmaceutical Chemistry Abramov A. U., Berlyand A. S., Garmonov S. Yu., Grebennikova T. V., Kalenikova E. I., Maksimova T. V., Morozova M. A., Pletneva T. V., Syroeshkin A.V., Uspenskaya, E. V., Shkrebneva I. I. M: Geotar Media. - 2017. - 816 p. Stamp Grif of the Ministry of Education and Science of the Russian Federation. ISBN 978-5-9704-4014-8
Abstract: The course-book outlines the basics of Pharmaceutical Chemistry in accordance with the program of discipline and the State standard for the speciality “Pharmacy”. The publication is intended for students of higher educational institutions studying in pharmaceutical, chemical-technological and other specialties, providing for the study of the course of Pharmaceutical Chemistry. The course-book can be recommended to postgraduate students of pharmaceutical specialties, as well as researchers and professors of the relevant departments.
https://istina.msu.ru/publications/book/31379140/
Toxicological Chemistry (course-book) (Pleteneva T. V., Syroeshkin A.V., Maksimova T. V.) RF, M.: Geotar Media. 2013. - 512 p. Stamp Grif of the Ministry of Education and Science of the Russian Federation.
Abstract: The presented material reflects the necessary information about the toxic-dynamic and toxic-kinetic regularities of absorption, distribution, biotransformation and excretion of xenobiotics, methods of their isolation from biomaterials and determination in acute and chronic poisoning. The problems of chemical and toxicological and forensic chemical analysis in poisoning by toxicants of different chemical classes are discussed.
http://medvetlit.ru/market/tematicheskij-prajs/toksikologiya-otravleniya/toksikologicheskaya-himiya-uchebnik-pleteneva-tv-syroeshkin-av-maksimova-tv-pod-red-tv-pletenvoj-2013-g/

Science

The intact DNA of terrestrial bacteria in cosmic dust of near-earth space was discovered (together with Professor Grebennikova T. V.).
The pharmaceutical composition for the prevention of tuberculosis was developed together with Professor Pleteneva T. V.
Original data on the state of the aero-disperse environment (size spectra, concentration and chemical composition of aerosols) of the Atlantic and Arctic oceans were obtained.
Systematic data for radiation monitoring thermal neutrons were obtained and describes the linkage between monitoring and species composition of biocenoses.
Physico-chemical and toxic properties of water, depleted in heavy isotopes were described for the first time (together with academician V. V. Goncharuk, professor Pleteneva T. V. and professor Burdeynaya T. N.).
The methodology of quasi-stationary chemical kinetics for quantitative description of bacterial communities, circulation of infectious diseases in places of a mass congestion of birds, spore survival and dormant forms of prokaryotes and eukaryotes was applied.
General pharmacopoeia article 1.2.1.0008.15 “Determination of particle size by laser light diffraction”, first in SP XIII was developed.
The method of determining the position of the epicentral zone of the source and the velocity of propagation of moving ionospheric disturbances was invented (Tertyshnikov A. V., Pisanko Y. V., Paley A. A., Syroeshkin A. V., etc.). RF patent number RU (11) 2 560 525 Published: 20.08.2015 Bull. No. 23. Russia, Moscow, 4 p.

Scientific interests

Kinetics of cellular processes;
Micronutrients in living systems;
Ecological Toxicology.

Syroeshkin, A.V., Antipova, N.V., Zlatska, A.V., Zlatskiy, I.A., Skylska, M.D., Grebennikova, T.V., Goncharuk, V.V. The effect of the deuterium depleted water on the biological activity of the eukaryotic cells Journal of Trace Elements in Medicine and Biology. V. 50, 2018, P. 629-633

Here we show the dependence of the unicellular biosensor S.ambigua lifespan on the water D/H isotopic composition. This dependence is bell-shaped with descents both in case of deficiency or excess of deuterium in water. The influence of the water D/H isotopic composition on the cell culture proliferative potential and colony forming efficiency in vitro was tested on the human dermal fibroblasts. We observed that the deuterium depleted water stimulates cell colony formation at the early passages. The dynamics of the cell doubling index in the deuterium depleted water-based growth medium showed higher proliferation potential compared to the water with normal isotopic composition. Using scratch assay, we have also studied the impact of the growth medium D/H isotopic composition on the cell motility of human cancer cell lines A549 and HT29. We have shown that the deuterium depleted water considerably suppressed cancer cell lines amoeboid movement in vitro.

Uspenskaya, E.V., Anfimova, E.V., Syroeshkin, A.V., Pleteneva, T.V. Kinetics of Active Pharmaceutical Ingredient Solubility in Water with Different Hydrogen Isotopic Content INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES. Т.: 80, Выпуск: 2, 2018, Стр.: 318-324. DOI: 10.4172/pharmaceutical-sciences.1000360

Kinetic analysis by means of low-angle laser light scattering has been used for the investigation into active pharmaceutical ingredients solubility depending on the content of heavy isotope of hydrogen H-2(1) (D) in water. Rate constants of active pharmaceutical ingredient solubility differ approximately by similar to 1.5 times for the two types of water with different deuterium/protium ratios, natural deionized high-ohmic water (D/H= 140 ppm) and deuterium-depleted water (D/H= 4 ppm). Results are to be utilized in order to control the quality of pharmaceutical substances with the purpose of dissolution quantitative evaluation, as well as with the aim of tackling the issue of new active pharmaceutical ingredients' low solubility while developing drugs.

Goncharuk, V.V., Pshinko, G.N., Rudenko, A.V., Pleteneva, T.V., Syroeshkin, A.V., Uspenskaya, E.V., Saprykina, M.N., Zlatskiy, I.A. Genetically Safe Drinking Water. Requirements and Methods of Its Quality Control JOURNAL OF WATER CHEMISTRY AND TECHNOLOGY. Т.: 40, Выпуск: 1, 2018, Стр.: 16-20. DOI: 10.3103/S1063455X18010034

The article contains a substantiation of a necessity of a new standard for assessment of the quality of genetically safe drinking water designed for consumption by man. Requirements to the quality of such water include 76 indices and are presented by 10 individual groups; extended is the number of indices of drinking waters of the level of toxicity (biotesting in 7 test objects), normative references to the methods of their control.

Goncharuk, V.V., Pleteneva, T.V., Grebennikova, T.V., Syroeshkin, A.V., Uspenskaya, E.V., Antipova, N.V., Kovalenko, V.F., Saprykina, M.N., Skil'skaya, M.D., Zlatskiy, I.A. Determination of Biological Activity of Water Having a Different Isotope Ratio of Protium and Deuterium JOURNAL OF WATER CHEMISTRY AND TECHNOLOGY. Т.: 40, Вып.: 1, 2018, Стр.: 27-34. DOI: 10.3103/S1063455X18010058

Peculiarities of the vital activity of organisms at different concentrations of the D/H isotope ratio in water have been studied. It was established that many organisms react in different ways to both high and low concentrations of deuterium in water resulting in the reduction or enhancement of the activity of metabolic processes. However, the majority of test organisms have optimal indicators within the limits of natural D/H isotope ratio in water. The experiments with human cells in vitro revealed that the reduced deuterium concentrations significantly changed the vital activity indicators of cultures in deuterium-depleted water media. It was found out that not all taxonomic groups of organisms could be sensitive to changes of the D/H isotope ratio in water.

Goncharuk, V.V., Pleteneva, T.V., Rudenko, A.V., Syroeshkin, A.V., Kovalenko, V.F., Uspenskaya, E.V., Saprykina, M.N., Zlatskiy, I.A. Basic Principles of Comprehensive Biotesting of Drinking Water and Point System Classification of Water Quality JOURNAL OF WATER CHEMISTRY AND TECHNOLOGY. Т.: 40, Вып.: 1, 2018 Стр.: 35-39. DOI: 10.3103/S1063455X1801006X

Basic principles of forming test systems for biotesting of natural and drinking waters, and the factors affecting test-systems during the biotesting procedure have been studied. New directions of selecting sensitive test reactions of organisms and test criteria for the quality assessment of natural and drinking waters based on the results of comprehensive biotesting are proposed. The universal point system for drinking water quality estimation was developed. It is based on summation of biotesting results using 4-5 species of animal and plant test-organisms of different systematic and trophic levels. In addition, the total toxicity index of water samples under investigation was also developed. The findings were used in the preparation of the State Standard of Ukraine "Quality of water. Comprehensive biotesting of natural water. Requirements to the selection and cultivation of test organisms. Water quality classification based on the point system".

Goncharuk, V.V., Syroeshkin, A.V., Pleteneva, T.V., Uspenskaya, E.V., Levitskaya, O.V., Tverdislov, V.A. On the Possibility of Chiral Structure-Density Submillimeter Inhomogeneities Existing in water JOURNAL OF WATER CHEMISTRY AND TECHNOLOGY. Т.: 39, Вып.: 6, 2017, Стр.: 319-324. DOI: 10.3103/S1063455X17060029

The existence of stable formations representing submillimeter density inhomogeneities in aqueous solutions was confirmed by using the laser light diffraction (LALLS) method and also the dynamic (DLS) and two-dimensional light scattering methods. The effect of low angle light scattering by giant water clusters depends on the presence of ions or dissolved substances in water solution, and also on the concentration of deuterium (heavy hydrogen isotope). It has been shown that the reduction of deuterium concentration results in the reduction of light scattering ability of protein nanoparticle preparations and water. The formation of long-living discrete water cluster structures possessing chiral properties was substantiated for explaining the manifestation of effects of weak impacts and low concentrations on biological objects.

Goncharuk, VV; Pleteneva, TV; Uspenskaya, EV; Syroeshkin, AV Controlled Chaos: Heterogeneous Catalysis JOURNAL OF WATER CHEMISTRY AND TECHNOLOGY. Т.: 39, Вып.: 6, 2017, Стр.: 325-330. DOI: 10.3103/S1063455X17060030

A technique for controlling the catalytic process using the impact on heterogeneous catalyst capable of staying in at least two conformational states has been described. The distinctive feature of conformers is their topological difference in the region of space of no less than 1 nm(3). Binding of ligands or the presence of high intensity electric field makes it possible to change in a specified way the catalyst affinity to reaction's substrates/products.

Goncharuk, V.V., Romanyukina, I.Y., Skil'skaya, M.D., Marynin, A.I., Syroeshkin, A.V., Dolenko, S.A. The impact of temperature on the degree of structurization of water of different isotope composition JOURNAL OF WATER CHEMISTRY AND TECHNOLOGY. Т.: 39, Вып. 4, 2017, Стр.: 185-190. DOI: 10.3103/S1063455X17040014

Using vacuum ultrafiltration radiation and the method of dynamic light scattering employing samples of light (D/H = 6 ppm), distilled (D/H = 150 ppm ) water and the water with an increased content of deuterium (D/H = 7700 ppm, 99.96%) as an example within the interval 4-80A degrees C the impact of temperature on the degree of water structurization of the different isotope composition was studied. Experimentally has been established the sizes of optical inhomogeneties of studied waters at various temperatures. It has been shown that temperature relationships of these types of water obtained by these methods have a graded nature with clear-cut critical points at 4; 36; 45 and 60-70A degrees C.

Goncharuk, V.V., Syroeshkin, A.V., Zlatskiy, I.A., Uspenskaya, E.V., Orekhova, A.V., Levitskaya, V., Dobrovolskiy, V.I., Pleteneva, T.V. Quasichemical Description of the Cell Death Kinetics of Cellular Biosensor Spirostomum Ambigua for Testing the Biological Activity of Aqueous Solutions JOURNAL OF WATER CHEMISTRY AND TECHNOLOGY. Т. 39, Вып.: 2, 2017, Стр.: 97-102. DOI: 10.3103/S1063455X17020072

A kinetic method of biotesting of aqueous solutions using isolated cells of unicellular organism Spirostomum ambigua has been described. A kinetic scheme of interaction of cellular biosensor with ligands based on the Michaelis-Menten mechanism was proposed. It was shown that the death rate of S. ambigua featured the Arrhenius-type dependence on temperature. The activation energy was determined for different toxicants and drugs. For many compounds the activation energy of slow stage of the process of cellular biosensor death linearly correlates with parameter DL50 for the same substances at their oral administration to laboratory animals.

Goncharuk, V.V., Syroeshkin, A.V., Kovalenko, V.F., Zlatskiy, I.A. Formation of a test system and the choice of test criteria when biotesting natural waters Journal of Water Chemistry and Technology. Т.: 38, Вып.: 6, 2016, Стр.: 349-352. DOI: 10.3103/S1063455X16060084

Described are main problems of biotesting natural water. Defined are principles for formation of a test system and factors influencing it. Proposed are main areas for the choice of sensitive test reaction of organisms and test criteria for assessing the quality of natural water by the results of their biotesting.

Information about the defended postgraduate students

Alexander Ul'yantsev
Country: Russia
Year of protection: 2010
Research topic: Development of an laser method for the determine of the identity of liquid dosage forms
Annotation to the dissertation: The work devoted to the development of a new laser method for the determine the identity of liquid dosage forms without opening the package for introduction into the practice of express analysis.

Musa Pateev
Country: Russia
Year of protection: 2009
Research topic: Interphase and transboundary transport of heavy metals in coastal and estuarine areas of the southern seas of Russia
Annotation to the dissertation: The work devoted to the description of transport and the path of a pollutant’saccumulation in water, marine aerosols and bottom sediments of marine coastal zones leading to the most dangerous concentration of toxicants in a marine aerosol.

Juliana Nikolaeva
Country: Russia
Year of protection: 2008
Research topic: Research of stability mechanisms of heterotrophic organisms to unfavorable abiotic factors using the example of Artemiasalina cysts
Annotation to the dissertation: The work devoted to the study of mechanisms of stability a cysts of Artemiasalina to unfavorable temperature effects and the neutron flux with different intensities

Elena Uspenskaya
Country: Russia
Year of protection: 2007
Research topic: The study of a supramolecularwater structure for the development of new methods for standardization and quality control of mineral waters and liquid dosage forms
Annotation to the dissertation: The work devoted to the study of a supramolecular water heterogeneity for the development of new methods for standardization and quality control of table mineral waters and liquid dosage forms.

Pavel Popov
Country: Russia
Year of protection: 2006
Research topic: Development of elements of the combined system QSAR analysis – “Quantitative structure-activity relationship”
Annotation to the dissertation: The work devoted to the study of new modern methods for predicting the drug’s biological activity and quality control on the basis of topological calculations.

Alexander Balyshev
Country: Russia
Year of protection: 2005
Research topic: Development and study of the biological activity of a pharmaceutical composition based on a zinc (II) salt and glycine
Annotation to the dissertation: The work devoted to the development of a new highly effective, non-toxic Zn2 + -containing pharmaceutical composition that prevents the formation of nonphagocytosed colonial and ultra-small forms of mycobacterium tuberculosis and stimulates the activity of factors of cellular immunity.

Olga Suzdaleva
Country: Russia
Year of protection: 2004
Research topic: The study of trace element composition and biological activity of a number of mineral waters
Annotation to the dissertation: The work devoted to revealing the connection between the content of trace elements of metals and the biological activity of mineral waters as combined preparations of inorganic nature.

Svetlana Bykanova
Country: Russia
Year of protection: 2003
Research topic: Development and standardization of the drug based on amino acids and the rationale for the economic efficiency of its production
Annotation to the dissertation: The work devoted to the development of the composition, the technology of preparation of the amino-acid drug, its standardization, the determination of the mechanisms of biological activity and the determination of the economic costs of its production.