Arfenya Karamyan
Candidate of Veterinary Sciences

“It is a special honor to belong to the number of people who devote all their energy to thinking about and researching objective facts of imperishable significance” 
A. Einstein


Graduated with honors from the Agrarian Faculty of the Peoples’ Friendship University of Russia (RUDN) on speciality “Veterinary Medicine”.


Graduated with honors from the Agrarian Faculty of the Peoples’ Friendship University of Russia (RUDN) on speciality “Economics and management of the agro-industrial complex”.

2006 - 2009

Post-graduate studies at the Department of Veterinary Pathology of the Agrarian Faculty RUDN. Candidate thesis on “Morpho-functional status of the mink organism in hepato-enteropathies and justification for its correction” was defended. 

2006 - 2013

Senior lecturer of the Department of Veterinary Pathology of the Agrarian Faculty RUDN.

2010 - present

Director of the center for diagnostic research of the Shared Research and Educational Center of the RUDN.

2013 - present

Associate professor of the Department of Clinical Veterinary Medicine of the Agrarian faculty RUDN (since 2016 - Department of Veterinary Medicine of the Agrarian and Technological Institute RUDN).


Gives lectures to students of bachelor’s and master’s programs, direction “Veterinary and Sanitary Expertise” of the Agrarian and Technological Institute RUDN University:

  • “Clinical diagnostics of animals”,
  • “Histology, Cytology, Embryology of animals”,
  • “Laboratory diagnostics of animals”.


  • Co-author of the patent “Quickly dissolving transbuccal film for the depressive disorders, anxiety and adaptation disorders treatment” (patent RU2622018). This dosage form in the form bio-adhesive films with a high bioavailability of the peptide. The invention will help expand the arsenal of controlled-release drugs for the depressive disorders, anxiety and adaptation disorders treatment in human.
  • Co-author of the patent “Filler for capsular inhaler” (patent RU2634258). The invention expanded the arsenal of medicines that provide delivery of the drug to the blood in an unchanged form, for inhalation administration in the autoimmune diseases treatment. The invention relates to the chemical and pharmaceutical industry and concerns capsules with a powder pharmaceutical inhalation composition for the autoimmune diseases treatment. The filler for capsular inhaler contains thymodepressin in the form of fine particles of respirable sizes.

Scientific interests

  • Preclinical research;
  • Development and research of a new dosage form;
  • Development of fillers for inhalers;
  • Development of transbuccal films;
  • Metabolomics;
  • Personalized medicine;
  • Diagnostics of animal diseases;
  • Experimental modeling of diabetes mellitus in laboratory animals;
  • Experimental models of stress in laboratory animals.
The purpose of this study was to quantify the serum blood biomarkers of the inflammatory process induced by subcutaneous injection of 0.1% Carrageenan solution into the rat paw. There are a variety of endogenous compounds participate in the process of inflammation, which can be divide into two groups: pro-inflammatory (inducing inflammatory reaction) and anti-inflammatory (concluding inflammation). Over time, their ratio may vary. Analysis of the rat blood serum metabolome after 3 and 24 hours (n=3) after the onset of the inflammatory reaction was carried out using HPLC/MS/MS equipment (Shimadzu 8040), Lipid Mediators v.2 and SPE (Chromabond HR-X 60 mg cartridges). From the obtained profile of metabolites, the prostaglandin groups of 8-iso-PGE2, PGE2, PGD2 (pro-inflammatory) and 8-iso-PGA2, PGA2, PGJ2 (anti-inflammatory) were chosen. A change in the ratio of these molecules during growth and resolution of inflammation in the Carrageenan-induced edema of the rat paw has been established. Quantity of the selected metabolites was expressed using relative units (RU) through normalization 8-iso-PGE2, PGE2, PGD2 to PGE2-d4 and 8-iso-PGA2, PGA2, PGJ2 to PGA2-d4. Control values in rats without inflammation were 48.57 RU and 8.03 RU for the sum of 8-iso-PGE2, PGE2, PGD2 and the sum of 8-iso-PGA2, PGA2, PGJ2, respectively. 3 hours after the onset of inflammation, the amount of pro-inflammatory metabolites was 135.22 RU, while for 24 hours 91.72 RU. For the anti-inflammatory metabolites group, 10.18 RU was determined for 3 hours, and 10.34 RU for 24 hours. Thus, there was an increase and a subsequent decrease in the number of pro-inflammatory prostaglandins, whereas the amount of anti-inflammatory drugs by 24 hours remained high. An analysis of the ratio of pro- and anti-inflammatory mediators in vivo using the model of Carrageenan-induced edema of the rat paw can be used to compare the anti-inflammatory activity of potential drugs. The determination of the metabolic profile kinetics during inflammatory process makes it possible to clearly demonstrate inhibition of the inflammatory cascade, and the prevention from transition acute form of inflammatory to chronic.
Familial Shar-Pei amyloidosis is an autoinflammatory systemic disease characterized by pathological synthesis of the fibrillary protein in the cells of the reticuloendothelial system, followed by amyloid formation. The purpose of our research is mainly focused on the investigation of specific structural histological changes in kidneys, liver, and spleen of the Shar-Pei dogs suffering from familial amyloidosis. Materials and Methods: The studies included autopsy and post-mortem examination of the Shar-Pei dogs with the presumptive diagnosis of familial amyloidosis or other diagnoses. Samples of kidney, liver, and spleen tissues of all cadavers were collected for histological examination. Results: Our studies showed that amyloid was formed within the ground substance of the connective tissue. Early amyloid deposits were observed in the spleen samples, providing the pathomorphological marker of the initial stage of the process generalization, whereas during the later stages, amyloid was found in kidneys, liver, and myocardium. Gradually increasing amyloid deposits lead to compression and atrophy of the parenchymal cells, sclerosis, and multiple organ dysfunction syndrome, manifesting as a wide range of clinical signs. Discussion: As a result of the conducted post-mortem examination, we have revealed systemic amyloidosis in the cadavers of the animals, initially admitted with various pathologies, which proves the importance and relevance of timely diagnostics, detection of clinical manifestations, and latent forms of the condition. Histological examination is one of the most accurate diagnostic methods for this pathology.
The lack of trace elements, including selenium, affects the metabolism of minks and the process of forming high-quality coat. Aim: To identify the relationship between metabolic processes and formation of coat by application of selenium preparations of inorganic nature in minks.
Difficulties in the early stage detection of erythrocytes’ microrheological abnormalities during the development of hypertension are connected with falling out of clinicians’ opinion of persons with first signs of this pathology. It dictates the necessity of experimental investigations’ fulfillment on laboratory animals with just developed hypertension in them. Eighty-seven of healthy male rats of Wistar line at the age of 2.5–3 months were taken into the investigation. Twenty-nine animals of them had experienced no impacts and composed the control group. Fifty-eight rats had hypertension developed by prescribing them cardio angionefo pathogenic semisynthetic diet. For the purpose of investigation biochemical, hematological, and statistical methods were used. As a result of hypertension, the rats turned out to have developed an increase of systolic and diastolic pressure. At regular exercise, on the treadmill, the rats were noted to have a gradual decrease of their values during 60 days of investigation to the normal level. During hypertension development lipids’ peroxidation activated in rats’ erythrocytes because the activity of their antioxidant protection weakened. When hypertension occurred in rats the erythrocytes-discocytes quantity in blood was found to have decreased. It was accompanied by an increase of reversibly and irreversibly changed erythrocytes quantity in the examined animals’ blood. When hypertension occurred in rats a quick rise of erythrocytes’ sum in aggregate was found and the rise in these aggregates’ quantity was due to lowering of free erythrocytes’ number. During experimental hypertension modeling, we noticed that there was a very early decrease in the quantity of erythrocytes-discocytes in the rat blood, and their level raised reversibly and irreversibly with the strengthening of their aggregative ability.

Information about the defended postgraduate students

Anna Savochkina
Country: Russia
Year of protection: 2017
Research topic: Clinical and morphological evaluation of the effect of medicinal forms of carprofen on the gastrointestinal tract of small animals
The direction of science: Veterinary Science and Zootechnics
Specialization: Diagnostics of diseases and therapy of animals, pathology, Oncology and morphology of animals
Annotation to the dissertation: Among the diseases of small animals acutely there is a problem of safe relief of pain of various Genesis, and also a question post-operative analgesia. In this regard, frequency and wide range of applications nonsteroidal anti-inflammatory drugs (NSAIDs) in veterinary medicine are determined by the irreplaceability of this group of drugs in therapy diseases accompanied by inflammation and severe pain Drugs of this group have a specific negative impact on the metabolism of the mucosa the digestive tract, reducing its protective potential and resistance to damaging aggressive effects of Exo-and endogenous factors. Greatest characteristic manifestation of systemic adverse effects of these drugs on digestive organs is gastroenteropathy-pathology, characterized by the appearance of hemorrhagic inflammation of the mucosa, bleeding and erosion, as well as taking drugs of this group has negative effect on the functioning of the liver, kidneys and cardiovascular system.