expert ecology
physical and chemical research methods
NMR spectroscopy
mass-spectrometry
quantitative analysis of the composition and structure of substances
identification test and quality analysis of medicinal
food products and dietary supplements
analysis of natural organic raw material
crude oil and petroleum products
lignin
humates
1941
Born in Irkutsk.
1963
Obtained a specialist’s degree in Physics and Radio Physics at Irkutsk State University.
1963-1965
Junior Research Fellow of the Irkutsk Institute of Organic Chemistry of the USSR Academy of Sciences.
1966-1969
Postgraduate student of the Institute of Chemistry of Natural Compounds of the USSR Academy of Sciences, Moscow (currently, Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow).
1970
Defended his PhD thesis entitled “NMR spectroscopy of vinyl ethers”.
1969-1971
Junior Research Fellow of the All Soviet Institute of Medicinal and Aromatic Plants.
1970-1983
Worked at the Institute of Petro- and Coal-chemical Synthesis of Irkutsk State University in different posts from a Junior Research Fellow to the Head of Laboratory of Physical Research Methods.
1982
Presented doctoral thesis entitled “NMR Spectrometry of Organic Chalcogenides” and obtained a doctoral degree in Organic Chemistry.
1983-1998
Head of the Department of Analytical Chemistry of Irkutsk State University (ISU).
1987-1998
Dean of the ISU Department of Chemistry.
1995-present
Full member of the Russian Ecological Academy.
1997
Awarded the title of Honorary Higher Vocational Education Worker of the Ministry of Education of the Russian Federation.
1998-present
RUDN University Professor of the Department of Systems Ecology.
2008-present
Director of the RUDN University Core Facility (Academic and Educational Centre) Centre for Precision Instrumental Methods of Analysis. Vice-President of the Russian Ecological Society.
Science
- Gennadii A. Kalabin developed principles and methods of analysis of natural organic raw material and products of its processing using the method of quantitative 1Н, 2Н, 13С, 17О NMR spectroscopy. On the basis of these methods the fractional composition of oil is studied, monitoring of synthesis of antioxidants, biodegradation of oil pollution, processing of rubber waste, quality control of widely used pharmaceutical drugs and biologically active supplements, etc. are carried out.
- Author of 7 monographs devoted to different aspects of applying NMR spectrosсopy. The most significant among them is Quantitative NMR spectroscopy of organic raw material and products of its processing (Moscow, Chemistry ed., 2000, 408 p.), based only on the research results of the scientific school of chemists-spectroscopists founded by Gennadii A. Kalabin.
- During his work at Irkutsk State University he created an Analytical Centre and specialization «Expert Chemistry» on its basis.
- In 2001-2003 he developed a project of an analytical centre for doing research in the analysis of complex organic objects using a set of independent and complementary physical and chemical methods. The project was implemented under the RUDN University Core Facility, which currently deals with the research of quality and composition of food, medicinal products and dietary supplements, petroleum products, etc. and other kinds of research.
- Author/co-author of three patents, the latest is Method of determination of metallurgical coke strength, 2008.
Areas of expertise
- Identification and authentication of food products and medicinal substances,
- early diagnosis of diseases on the basis of the composition of human biofluids (metabolomics),
- forecast of properties of humates, lignins, petroleum products based on their spectral descriptors.
The structures of zinc (2), copper(II) (3), and calcium (4) complexes with trans-2R, 3R-dihydroquercetin (1) have been elucidated by IR, 2D NMR, mass spectrometry DART techniques, term gravimetric analysis using data from elemental and microscopic energy dispersive X-ray analyses. The redox properties of complexes 2-4 were studied by cyclic voltammetry.
The authors prove relevance of digital space data to be used for regional and local operational quantitative estimation of nature in the area of mineral mining and processing. The research findings are analyzed in terms of environmental appraisal made for the area of an open pit mine at Gusevogorskoe deposit of titano-magnetite ore with vanadium admixture (Sverdlovsk Region, Russia).
A new method was proposed for the evaluation of aromaticity (the percentage of aromatic C atoms in crude oil and petroleum products) based on 1H NMR spectra.
Results of a comparative analysis of the use of quantitative NMR spectroscopy for the quality control of pharmaceuticals and drugs are presented. Diquertin, the active principle of which is the common flavonoid dihydroquercetin (taxifolin, 3,3′,4′,5,7-pentahydroxyflavanone), was used as an example. Quantitative 1H NMR spectroscopy can be recommended on the basis of this comparative analysis for use when it is necessary to identify all possible impurities or to confirm the absence of toxic contaminants and also for rapid analysis of samples.
The unity, interrelationship, and interdependence of the processes proceeding in anthropogenic provinces caused by the activity of mining industries are considered from the viewpoint of the concept of hierarchical passivity of natural components. The processes of degradation of natural complexes under the influence of mining industries and the processes of rehabilitation of the vegetation cover when the anthropogenic pressure decreases are analyzed taking the ZAO Karabashmed’, Chelyabinsk region, and the Severonikel’ Combine, Murmansk region, as examples. The intrinsic potential of rehabilitation of natural systems (air, water, and soil) is assessed, and the most passive components are identified. A strategy of reclamation of disturbed territories is enunciated based on the information obtained taking the natural self-recovering ability of ecosystems in different climate zones into account.
The composition of terpen lactones and flavonol glycosides of commercial preparation series based on Ginkgo biloba extracts was investigated by 1H NMR spectroscopy. The content of individual terpen lactones was determined using DMSO-d6 and acetone-d6 solvents. The effect of the structure of flavonol glycosides on the signal of the hydroxyl proton at a position 5 of the ring A was examined. A new approach was proposed for semiquantitative determination of the total amount of flavonol glycosides by the integral intensity of this signal, which is a superposition of the singlets in the region of 12.5–12.65 ppm of individual flavonoids in DMSO-d6. Since the corresponding signals of aglycones (quercetin, kaempferol, isorhamnetin), which are minor components of the Ginkgo biloba extracts, appear separately in a slightly different region (12.45–12.48 ppm), the proposed method can also be used for detecting adulteration of Ginkgo biloba extracts by means of the addition into them of relatively cheap aglycones or rutin as well as for assessment of the content of flavonoids of similar structure in some types of plant raw materials.
Prokop'Ev, A.S., Ivlev, V.A., Vasil'Ev, V.G., Goryainov, S.V., Abramovich, R.A., Kalabin, G.A. New methodology for rapid monitoring of the authenticity and for determination of the pharmaceutical ingredients of antibiotics without the use of reference materials //Antibiotiki i KhimioterapiyaVolume 62, Issue 7-8, 2017, Pages 48-55
An analysis of some popular antibiotics was carried out by quantitative 1H NM R spectroscopy and DART mass spectrometry without the use of reference standards.
A new method for assaying the main components of Perftoran formulation based on 1H and 19F NMR spectroscopy was developed. The method was developed for inclusion in the Manufacturer’s Pharmacopeia Article for Perftoran.