Olga Potanina

Research and Innovation

RUDN Scientists

Olga Potanina

Doctor of Pharmaceutical Sciences

Shared Research and Educational Center RUDN University,

Knowledge is power.

Scientific interests:

pharmaceutical development of drugs pharmaceutical analysis State Pharmacopoeia herbal drugs biologically active compounds microscopy

1992

Graduated from the Faculty of Pharmacy of I. M. Sechenov Moscow Medical Academy, diploma with honors.

1995

Candidate thesis on “Pharmacognosy quality study of the black elderberry, red elderberry, elderberry Siberian” was defended. Degree - Candidate of Pharmaceutical Sciences.

2004

Doctoral thesis on “Improvement of standardization and quality control of medicinal plant raw materials and dosage forms from it on the basis of microscopic research method” was defended. Degree - Doctor of Pharmaceutical Sciences.

2004 - 2016

Leading researcher of the laboratory of pharmacognosy of the Research Institute of Pharmacy of I. M. Sechenov First Moscow State Medical University.

2010 - present

Director of the center for research and development of Shared Research and Educational Center RUDN University.

2015 - present

Acting head of the Department of Pharmaceutical Chemistry and Pharmacognosy of RUDN University, professor of the department.

2018 - present

Member of the Dissertation Council 0300.001 of RUDN University on scientific specialties 14.04.02 - Pharmaceutical Chemistry, Pharmacognosy (pharmaceutical Sciences); 14.03.06 - Pharmacology, Clinical Pharmacology (pharmaceutical Sciences).

2014 - present

Member of the Expert Qualification Commission of the Ministry of Health of the Russian Federation on the certification of experts for the right to carry out the examination of medicines for medical use.

2018 - present

Member of the Council of the Ministry of Health of the Russian Federation on the state Pharmacopoeia.

2013 - present

Scientific editor of “State Pharmacopoeia XIII” “State Pharmacopoeia XIV”.

Teaching

Potanina O. G. gives lectures to students of additional vocational education programs:

“Pharmaceutical Chemistry and Pharmacognosy”
“Pharmaceutical development”.

Science

Scientific interests

Co-author of 10 patents, including:
- Filler for capsule inhaler (RU 2634258 - the invention relates to the chemical and pharmaceutical industry and relates to capsules with a powder pharmaceutical inhalation composition for the treatment of autoimmune diseases),
- Rapidly dissolving transbuccal membrane for the treatment of depressive disorders, anxiety and adaptation disorders (RU 2634258 - the invention expanded the arsenal of drugs that provide delivery of the drug to the blood in an unchanged form, for inhalation administration in the treatment of autoimmune diseases),
- A multifunctional combined drug for the correction of immunodeficiency state and the treatment of severe infectious and inflammatory diseases (RU 2491087 - the invention relates to medicine and concerns a new multifunctional combined drug of a wide spectrum of action based on interferon),
- A method for determining the components of plant collection by microscopic method (RU 2144668 - the invention is intended for qualitative and quantitative determination of components in multicomponent plant powder collections. The method provides for improving the quality of control and simplifying it in the standardization of fees of the “tan” type).
Potanina O. G. is the author of more than 30 general Pharmacopoeia articles and Pharmacopoeia articles for the State Pharmacopoeia of the Russian Federation XIII edition and XIV edition on standardization of herbal medicines, including homeopathy.
More than 150 scientific and methodical works on standardization and quality control of medicinal plant raw materials and dosage forms from it were published.

Scientific interests

Pharmacognosy;
Pharmaceutical Chemistry;
technology of drugs;
pharmaceutical development of drugs;
research of herbal drugs;
standardization and quality control of drugs;
State Pharmacopoeia.

Nikulin, A.V., Yamshchikova, S.I., Potanina, O.G., Abramovich, R.A. Determination of reducing carbohydrate’s total and water-soluble polycarbohydrates in medicinal raw plants Journal of Biopharmaceuticals. -2018. -Volume 10. - Issue 5. -Pages 42-49

In the article was given data of determination of reducing carbohydrate’s total with UV-spectro-photometry and choise of conditions of a quantitative determination of a water-soluble polycarbohydrates with gravimetry in the medicinal raw plants. A reducing carbohydrate’s total and a water-soluble polycarbohydrates were determined in Althaeae radices, Arctium lappa L., Tussilaginis farfarae folia, Inulae rhizomata et radices, Lini semina, Violae herba, Tiliae flores, Taraxacum officinale wig., Plantaginis majoris folia.

Bokov D.O., Smyslova O.A., Litvinova T.M., Samylina I.A., Potanina O.G. Development and approval of quality standards for pharmaceutical substances of plant origin in the Russian Federation. J. Pharm. Sci. & Res. – 2018, – Vol. 10(7), PP. 1818-1819.

Analytical control of pharmaceutical substances and drugs of plant origin plays an important role in the quality assurance system for pharmaceutical products. The use of validated analytical methods for pharmacopoeial analysis is necessary in accordance with modern requirements for the medicines production. This article provides data on the validation procedure, the main parameters (specificity, detection limit, quantitation limit, range, linearity, trueness, precision, robustness). We discuss the parameters that must be assessed in order to validate the method for determining biologically active compounds in pharmaceutical substances of plant origin and herbal medicinal products taking into account specific requirements in the Russian Federation.

Abramovich R.A., Vasil'ev V.G., Goryainov S.V., Potanina O.G., Ossipov V.I. The metabolomic approach to the investigation of secondary metabolites of herbal samples

Metabolomics is a technology that includes a set of analytical and bioinformational methods for identifying and quantifying the aggregate of metabolites (metabolom) with low molecular weight in a cell, tissue or organism. The purpose of metabolomics is to determine changes in the biochemical phenotype of plants and to understand the functional signifi cance of these changes (genetic changes, the infl uence of various environmental factors, etc.). Analysis of plant metabolite is a complex task because of the wide range of differences in the physicochemical properties of the analyzed compounds (molecular weights from 50 to 1500 Da, polarity, volatility, thermolability) and detectable concentrations [1]. The main methods for studying plant metabolomics are high-performance liquid or gas chromatography with mass spectrometric detection and NMR spectroscopy. The use of methods of multivariate statistical analysis makes it possible to visualize differences in the metabolom of the compared groups of plants. Within the framework of the current cooperation agreement between the University of Turku (Finland) and RUDN University, the phenolic compounds of various medicinal plant raw materials (Lycopus europaeus, Tanacetum vulgare, Silybum marianum, Arctium lappa, Panax ginseng, Urtica dioica L., Aesculus hippocastanum, Hypericum perforatum, Сladonia stellaris) have been studied by high performance liquid chromatography with mass spectrometric detection. For each of the above plant species, their metabolic profi ling has been carried out.

Nikulin, A.V., Goryainov, S.V., Sinitcina, N.I., Lebedeva N.R., Potanina, O.G., Abramovich, R.A. Procedure of glucosamine determination in the gel by HPLC/MS Russian Journal of Biopharmaceuticals. -2017. -Volume 9. -Issue 1. - P. 9-13

Results of development of an effective procedure of glycosamine determination in the gel by HPLC/MS are represented in the article. The validation parameters are studied, the structure of a glycosamine is confirmed. The analysis data of three innovative preparation experimental series with content of a glycosamine sulfate sodium salt 8 % are described.