Tatyana Pleteneva

Research and Innovation

RUDN Scientists

Tatyana Pleteneva

Doctor of Chemistry

Professor,

Remember: physical chemistry and pharmaceutical analysis - is the brain and heart of pharmacy.

pleteneva-tv@rudn.ru

Contact a scientist

Scientific interests:

kinetic analysis bioequivalence bioactivity criteria preclinical studies metabolomics personalized medicine

1972

Graduated from Kazan State University (KSU, now - Kazan Federal University - KFU), Faculty of Chemistry, specialty - “Chemistry”.

1972 - 1978

Senior laboratory assistant / engineer / junior researcher / senior researcher of the laboratory of Physical Chemistry of the Institute of Chemistry of the Academy of Sciences of the USSR and the laboratory of Electrochemical Methods of Analysis of KSU.

1976

Candidate thesis on “Electrochemical study of amalgam onium radicals” was defended. Academic degree - Candidate of Chemical Sciences was awarded.

1979 - 1998

Assistant / senior lecturer / associate professor / professor of the Department of Physical and Colloidal chemistry, Faculty of Pharmacy, I. M. Sechenov Moscow Medical Academy.

1993

Doctoral thesis on “Prediction of biological activity of chemical compounds by physico-chemical methods” was defended. Academic degree - Doctor of Chemical Sciences was awarded.

1998 - 2015

Head of the Department of Pharmaceutical and Toxicological Chemistry of the Medical Faculty of RUDN University.

2001 - 2014

Deputy dean of the Medical Faculty of RUDN University, specialty “Pharmacy”.

2015 - present

Professor of the Department of Pharmaceutical and Toxicological chemistry of the Institute of Medicine RUDN University.

2015 - present

Head of the direction of postgraduate studies 33.06.01 “Pharmacy” RUDN University.

Teaching

Conducts lectures to RUDN students, specialty - “Pharmacy”, master's and postgraduate students:

“Pharmaceutical chemistry”,
“Biopharmaceutical analysis”,
“Physico-chemical bases of quality control of medicines”,
“Toxicological chemistry”.

The author of the following course-books and study guides:

Pharmaceutical Chemistry Abramov A. U., Berlyand A. S., Garmonov S. Yu., Grebennikova T. V., Kalenikova E. I., Maksimova T. V., Morozova M. A., Pletneva T. V., Syroeshkin A.V., Uspenskaya, E. V., Shkrebneva I. I. M: Geotar Media. - 2017. - 816 p. Stamp of the Ministry of Education and Science of the Russian Federation. ISBN 978-5-9704-4014-8
Abstract: The course-book outlines the basics of Pharmaceutical Chemistry in accordance with the program of discipline and the State standard for the speciality “Pharmacy”. The publication is intended for students of higher educational institutions studying in pharmaceutical, chemical-technological and other specialties, providing for the study of the course of Pharmaceutical Chemistry. The course-book can be recommended to postgraduate students of pharmaceutical specialties, as well as researchers and professors of the relevant departments.
https://istina.msu.ru/publications/book/31379140/
Toxicological Chemistry (course-book) (Pleteneva T. V., Syroeshkin A.V., Maksimova T. V.) RF, M.: Geotar Media. 2013. - 512 p. Stamp of the Ministry of Education and Science of the Russian Federation.
Abstract: The presented material reflects the necessary information about the toxic-dynamic and toxic-kinetic regularities of absorption, distribution, biotransformation and excretion of xenobiotics, methods of their isolation from biomaterials and determination in acute and chronic poisoning. The problems of chemical and toxicological and forensic chemical analysis in poisoning by toxicants of different chemical classes are discussed.
http://medvetlit.ru/market/tematicheskij-prajs/toksikologiya-otravleniya/toksikologicheskaya-himiya-uchebnik-pleteneva-tv-syroeshkin-av-maksimova-tv-pod-red-tv-pletenvoj-2013-g/

Science

The method of diagrams Pourbaix (“pH-potential”) to predict the biological activity of chemical compounds (drugs and toxicants) was applied for the first time.
The pharmaceutical composition for the prevention of tuberculosis was developed (together with professor Syroeshkin A.V.).
Physico-chemical and toxic properties of water, depleted in heavy isotopes were described for the first time (together with academician V. V. Goncharuk, professor Syroeshkin A.V and professor Burdeynaya T. N.).
General pharmacopoeia article 1.2.1.0008.15 “Determination of particle size by laser light diffraction”, first in State Pharmacotherapy (SP) XIII was developed.

Scientific interests

Chemical mechanisms of biological activity of xenobiotics;
Metabolites;
Combined toxicity;
Biopharmaceutical analysis and personalized medicine.

Syroeshkin, AV; Pleteneva, TV; Uspenskaya, EV; Levitskaya, OV Polarimetric Research of Pharmaceutical Substances in Aqueous Solutions with Different Water Isotopologues ratio. INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICS. V. 10. N5.2018.

In the optically active pharmaceutical substances quality control there should be considered the contribution of induced chiral GHC of water to the optical rotation value that depends on the isotopic D/H ratio, the substance nature and the form of its existence at given pH.

Uspenskaya, EV; Anfimova, EV;, Syroeshkin, AV; Pleteneva, TV Kinetics of Active Pharmaceutical Ingredient Solubility in Water with Different Hydrogen Isotopic Content INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES. Т.: 80, Выпуск: 2, 2018, Стр.: 318-324. DOI: 10.4172/pharmaceutical-sciences.1000360

Kinetic analysis by means of low-angle laser light scattering has been used for the investigation into active pharmaceutical ingredients solubility depending on the content of heavy isotope of hydrogen H-2(1) (D) in water. Rate constants of active pharmaceutical ingredient solubility differ approximately by similar to 1.5 times for the two types of water with different deuterium/protium ratios, natural deionized high-ohmic water (D/H= 140 ppm) and deuterium-depleted water (D/H= 4 ppm). Results are to be utilized in order to control the quality of pharmaceutical substances with the purpose of dissolution quantitative evaluation, as well as with the aim of tackling the issue of new active pharmaceutical ingredients' low solubility while developing drugs.

Goncharuk, VV; Pshinko, GN; Rudenko, AV; Pleteneva, TV; Syroeshkin, AV; Uspenskaya, EV; Saprykina, MN; Zlatskiy, IA Genetically Safe Drinking Water. Requirements and Methods of Its Quality Control JOURNAL OF WATER CHEMISTRY AND TECHNOLOGY. Т.: 40, Выпуск: 1, 2018, Стр.: 16-20. DOI: 10.3103/S1063455X18010034

The article contains a substantiation of a necessity of a new standard for assessment of the quality of genetically safe drinking water designed for consumption by man. Requirements to the quality of such water include 76 indices and are presented by 10 individual groups; extended is the number of indices of drinking waters of the level of toxicity (biotesting in 7 test objects), normative references to the methods of their control.

Goncharuk, VV; Pleteneva, TV; Grebennikova, TV; Syroeshkin, AV; Uspenskaya, EV; Antipova, NV; Kovalenko, VF; Saprykina, MN; Skil'skaya, MD; Zlatskiy, IA Determination of Biological Activity of Water Having a Different Isotope Ratio of Protium and Deuterium JOURNAL OF WATER CHEMISTRY AND TECHNOLOGY. Т.: 40, Вып.: 1, 2018, Стр.: 27-34. DOI: 10.3103/S1063455X18010058

Peculiarities of the vital activity of organisms at different concentrations of the D/H isotope ratio in water have been studied. It was established that many organisms react in different ways to both high and low concentrations of deuterium in water resulting in the reduction or enhancement of the activity of metabolic processes. However, the majority of test organisms have optimal indicators within the limits of natural D/H isotope ratio in water. The experiments with human cells in vitro revealed that the reduced deuterium concentrations significantly changed the vital activity indicators of cultures in deuterium-depleted water media. It was found out that not all taxonomic groups of organisms could be sensitive to changes of the D/H isotope ratio in water.

Goncharuk, VV; Pleteneva, TV; Rudenko, AV; Syroeshkin, AV; Kovalenko, VF; Uspenskaya, EV; Saprykina, MN; Zlatskiy, IA Basic Principles of Comprehensive Biotesting of Drinking Water and Point System Classification of Water Quality JOURNAL OF WATER CHEMISTRY AND TECHNOLOGY. Т.: 40, Вып.: 1, 2018 Стр.: 35-39. DOI: 10.3103/S1063455X1801006X

Basic principles of forming test systems for biotesting of natural and drinking waters, and the factors affecting test-systems during the biotesting procedure have been studied. New directions of selecting sensitive test reactions of organisms and test criteria for the quality assessment of natural and drinking waters based on the results of comprehensive biotesting are proposed. The universal point system for drinking water quality estimation was developed. It is based on summation of biotesting results using 4-5 species of animal and plant test-organisms of different systematic and trophic levels. In addition, the total toxicity index of water samples under investigation was also developed. The findings were used in the preparation of the State Standard of Ukraine "Quality of water. Comprehensive biotesting of natural water. Requirements to the selection and cultivation of test organisms. Water quality classification based on the point system".

Goncharuk, VV; Syroeshkin, AV; Pleteneva, TV; Uspenskaya, EV; Levitskaya, OV; Tverdislov, VA On the Possibility of Chiral Structure-Density Submillimeter Inhomogeneities Existing in water JOURNAL OF WATER CHEMISTRY AND TECHNOLOGY. Т.: 39, Вып.: 6, 2017, Стр.: 319-324. DOI: 10.3103/S1063455X17060029

The existence of stable formations representing submillimeter density inhomogeneities in aqueous solutions was confirmed by using the laser light diffraction (LALLS) method and also the dynamic (DLS) and two-dimensional light scattering methods. The effect of low angle light scattering by giant water clusters depends on the presence of ions or dissolved substances in water solution, and also on the concentration of deuterium (heavy hydrogen isotope). It has been shown that the reduction of deuterium concentration results in the reduction of light scattering ability of protein nanoparticle preparations and water. The formation of long-living discrete water cluster structures possessing chiral properties was substantiated for explaining the manifestation of effects of weak impacts and low concentrations on biological objects.

Goncharuk, VV; Pleteneva, TV; Uspenskaya, EV; Syroeshkin, AV Controlled Chaos: Heterogeneous Catalysis JOURNAL OF WATER CHEMISTRY AND TECHNOLOGY. Т.: 39, Вып.: 6, 2017, Стр.: 325-330. DOI: 10.3103/S1063455X17060030

A technique for controlling the catalytic process using the impact on heterogeneous catalyst capable of staying in at least two conformational states has been described. The distinctive feature of conformers is their topological difference in the region of space of no less than 1 nm(3). Binding of ligands or the presence of high intensity electric field makes it possible to change in a specified way the catalyst affinity to reaction's substrates/products.

Goncharuk, VV; Syroeshkin, AV; Zlatskiy, IA; Uspenskaya, EV; Orekhova, AV; Levitskaya, V; Dobrovolskiy, VI; Pleteneva, TV Quasichemical Description of the Cell Death Kinetics of Cellular Biosensor Spirostomum Ambigua for Testing the Biological Activity of Aqueous Solutions JOURNAL OF WATER CHEMISTRY AND TECHNOLOGY. Т. 39, Вып.: 2, 2017, Стр.: 97-102. DOI: 10.3103/S1063455X17020072

A kinetic method of biotesting of aqueous solutions using isolated cells of unicellular organism Spirostomum ambigua has been described. A kinetic scheme of interaction of cellular biosensor with ligands based on the Michaelis-Menten mechanism was proposed. It was shown that the death rate of S. ambigua featured the Arrhenius-type dependence on temperature. The activation energy was determined for different toxicants and drugs. For many compounds the activation energy of slow stage of the process of cellular biosensor death linearly correlates with parameter DL50 for the same substances at their oral administration to laboratory animals.

Levitskaya, OV; Syroeshkin, AV; Pleteneva, TV Arrhenius kinetics as a bioactivity assessment criterion for drug substances and excipients PHARMACEUTICAL CHEMISTRY JOURNAL. Т.: 49, Вып.: 11, 2016, Стр.: 779-781 DOI: 10.1007/s11094-016-1370-9

Arrhenius kinetic principles, in particular, E-a values, were used to assess the biological activity of drug substances in aqueous solutions with different D/H ratios. The obtained activation energies indicated that deuterium-depleted solutions had lower toxicity and biological activity.

Information about the defended postgraduate students

Olga Levitskaya
Country: Belarus
Year of protection: 2016
Research topic: Interactions between pharmaceutical substance and excipients in aqueous solutions with different Deuterium/Hydrogen composition
Annotation to the dissertation: The research is devoted to the study of interactions of pharmaceutical substances and excipients in the composition of finished drugs, as well as the influence of isotopic composition of water on biological activity and optical properties of BAS.

Samvel Barseghyan
Country: Russia
Year of protection: 2013
Research topic: Development and optimization of methods for determination of opiate alkaloids and their derivatives in narcotic drugs and biological materials
Annotation to the dissertation: The research is devoted to one of the main tasks of criminology and forensic chemistry, which is identification and determination of drug content in biological materials and physical evidence. High-performance liquid chromatography (HPLC) was applied to solve this problem. The application of reliable results of the analysis will increase the objectivity of the examination in administrative and criminal cases.

Maria Morozova
Country: Russia
Year of protection: 2012
Research topic: New approaches to the quality control of medicines based on spectrometry in the near infrared region
Annotation to the dissertation: The study is devoted to the development of new methods of pharmaceutical substance (PS) analysis based on the method of spectroscopy in the near infrared region. On the first place the variability of NIR spectra in the analysis of drugs in massive production was assessed. The correlation between spectral characteristics and their quality indicators existing in the normative documentation on pharmaceutical substance is determined.

Anastasia Pronyaeva
Country: Russia
Year of protection: 2012
Research topic: Influence of adverse environmental factors on the occurrence of systemic hypoplasia of the enamel of permanent teeth in children
Annotation to the dissertation: The research is focused on the improvement of diagnosis, prevention and treatment of dental enamel hypomineralization in children on the basis of examination of influence of adverse environmental factors ю

Tatyana Elizarova
Country: Russia
Year of protection: 2009
Research topic: Spectroscopy in the near infrared region as a method of medicines quality control
Annotation to the dissertation: The study is focused on the research of the possibility of IR spectrometry in the near range for rapid analysis of medicinal substances and complete dosage forms.

Natalya Parshina
Country: Russia
Year of protection: 2009
Research topic: Biopharmaceutical study of gemcitabine: antineoplastic drugs belonging to the group of antimetabolites
Annotation to the dissertation: The study is focused on the development of a system for therapeutic drug monitoring for gemcitabine in patients with pancreatic cancer and Hodgkin's lymphoma based on methods of quantitative determination in drug and blood plasma, HPLC method and kinetics control of general clinical and biochemical parameters.

Veronica Ivanova-Radkevitch
Country: Russia
Year of protection: 2009
Research topic: In vivo screening studies of new photosensitizer for malignant tumors photodynamic therapy
Annotation to the dissertation: This study focuses on cytotoxic and photodynamic properties of new compounds synthesized by Research Institute of organic semi-products and dyes of polymers State scientific center, examining the potential photosensitizers for PDT of malignant tumors.

Irina Luzanova
Country: Russia
Year of protection: 2008
Research topic: Development and optimization of techniques for s-, p-, d-elements identification in biomaterials at chemo-toxicological and forensic medical studies
Annotation to the dissertation: The research is devoted to the development of General methodological approaches for toxic metals and amphoteric elements identification in chemical, Toxicological, forensic and forensic studies.

Constantin Koshetchkin
Country: Russia
Year of protection: 2008
Research topic: Calcium folate antidote properties biopharmaceutical analysis in high-dose chemotherapy with methotrexate osteosarcoma in children
Annotation to the dissertation: The study is devoted to the development of a method for quantitative identification of Ca-folate in injectable drugs (PS) of various manufacturers on HPLC, and bio-kinetics evaluation of the antidote activity of Ca-folate in HDCT methotrexate OS in children.

Pavel Popov
Country: Russia
Year of protection: 2006
Research topic: Development of elements in combined system "quantitative correlation structure-property" for the study of medicines
Annotation to the dissertation: The research is dedicated to the development of new modern methods of prediction to the biological activity of drugs and quality control on the basis of topological calculations

Natalya Denisova
Country: Russia
Year of protection: 2003
Research topic: Study of the efficacy and safety of Consupren after allogenic renal transplantation
Annotation to the dissertation: The study is to evaluate the safety and efficiency of a new Cyclosporine A containing drug called "Consupren" during six months of use in patients after allogenic kidney transplantation.