Events

The “theranostic” approach currently revolutionizing diagnosis and treatment of disease in nuclear medicine has been enabled by enhanced availability of new radionuclides, which are crucial for this technique. The development of complementary imaging and therapeutic compounds for the diagnosis and treatment of disease requires “isotopic pairs” or “matched pairs” where radiolabels are biochemically identical or similar (respectively), making them suitable for imaging and therapy.

Ultrasonic treatment of the reaction between chitosan and aromatic aldehyde, 4-formyl-3-hydroxy-5-hydroxymethyl-1,2-dimethylpyridin-1-ium iodide, resulted in its significant acceleration and increase in degree of derivatization. The CH=N bond of the prepared Schiff base was reduced, and the formed polymeric material was converted into the corresponding zinc (II) composite by treatment with ZnCl2 and NaOH. The obtained composite is non-toxic, possesses high antibacterial activity and can be employed as the catalyst in the Mannich reaction between benzaldehyde, phenylacetylene and piperidine.