Biologists of RUDN University found out what is the difference between the body's reaction to hypoxia at different ages

Biologists of RUDN University found out what is the difference between the body's reaction to hypoxia at different ages

RUDN biologists have determined how the body’s response to oxygen deficiency at the molecular level changes with age. These are the first results obtained in this direction - previously it was known only about the change in general resistance to low oxygen levelswithage.

Reduced oxygen content (hypoxia) is one of the main factors that can change the functional state of the whole organism. To some extent, the body is able to withstand hypoxia, but if its strength exceeds the adaptive capabilities of the body, then irreversible changes begin in the tissues. The main “conductor” that determinesthe level of adaptationof cells to hypoxiais HIFproteins. Until now, there have been no studies that have determined how HIFactivity changes withage. RUDN biologists conducted studies on rats and determined what happens to the level of this and other proteins in hypoxia in different age groups.

“Age plays an important role in the body’s resistance to hypoxia. Back in 1870, he found outthatnewborn animals are more resistant to low oxygen levels compared to adults. Nevertheless, little is known about the expression of HIF in organisms of different ages, ”- Doctor of Biological Sciences Anna Kosyreva, Associate Professor of the Department of Histology, Cytology and Embryology of RUDN University.

Biologists conducted an experiment on rats (36 males) from different age categories: 12 newborns(two days from birth), 12 rats of prepubertal age (10 days) and 12 adults (three months). 18 rats of all ages were placed in an oxygen-deficient chamber in conditions correspondingto an altitude of 11.5 thousand meters, and measuredafter what time the first signs of asphyxia — suffocation- wouldappear. Biologists measured the level of HIF and other proteins in rats that passed the hyperbaric chamber, and in those that remained in normalconditions.

The most sensitive to hypoxia were prepubertal rats. They began to lack air after 30 to40 seconds. Adult and newborn rats took 60 to120 seconds. The number of genes that are responsible for HIF was significantly higher in prepubertal rats and newborns than in adults. And the level of HIF was minimal in rats from two “younger” groups and maximum in adults. RUDN biologists explained this by the action of another protein — PHD2,which causes the breakdown of HIF

“In prepubertal animals, the expression rate of the HIF-1α gene was significantly higher than in adult animals. At the same time, PHD2 activity in prepubertal animals was significantly reduced compared to newborn rats, but the level of the HIF-1α protein did not change. In further studies, it is necessary to identify additional mechanisms that determine theregulation of the level of the HIF-1α protein in prepubertal animals. This study will give a new idea of age differences in resistance to hypoxia,” Polina Vishnyakova, Candidate of Biological Sciences, Employee of the Scientific and Educational Laboratory of Medical Biotechnologies of RUDN University.

The study is published in the journal Heliyon.

All news
20 Jan
RUDN University chemist creates nanocatalysts for vanillin synthesis

RUDN University chemist proposed a new method to create catalysts on a porous silicon matrix with metal nanoparticles. Efficient catalysts for organic reactions are obtained, for example, for the synthesis of vanillin, which is in demand in the food and perfume industry.

16 Jan
RUDN University Linguist: Intimidation and Military Rhetoric in the Media during the Pandemic Make People Pessimistic

When talking about COVID-19, television, newspapers, magazines, and social media turn to battle metaphors that make the fight against the pandemic feel like a war. Also, the coronavirus is often discussed in an excessively alarming and threatening tone. This problem is so acute that there is even the term for that — infodemia. It describes the panic in the media and social networks. A linguist of RUDN University studied how such a language affects the notions of people regarding COVID-19.

29 Dec 2022
RUDN University Ecologists Find a Flaw in Arable Soil Organic Matter Detection Using Optical Remote Sensing Data

Ecologists of the RUDN University showed that one of the methods used to detect the soil organic matter turns out to be ineffective after precipitation. Studies have shown that the impact of rain on the surface of arable soils leads to a decrease in the accuracy of modelling of organic matter content by 70%. The ecologists also suggested the way to compensate for this negative phenomenon and increase the accuracy of calculations to 84%.