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The chemist from RUDN University, together with the colleagues, first created molecules’ catchers for energy source molecules of cells

The chemist from RUDN University, together with the colleagues, first created molecules’ catchers for energy source molecules of cells

For the first time, a team of Russian scientists together with RUDN University synthesized calixarenes capable of “trapping” adenosine triphosphoric acid (ATA) molecules and enclosing them inside their cavity. ATA molecules are a universal source of energy for most biochemical processes. They also act as an intercellular mediator.

The authors created a kind of molecular sensor that can not only recognize the ATA molecule among others, but also “capture” it. This was achieved thanks to the attachment to the upper part of the "bowl" of molecular receptors - groups of atoms that selectively bind only to compounds of a certain type. The atomic groups containing nitrogen introduced by scientists have shown high efficiency in the binding of ATA in solution.
Scientists synthesized several types of calixarenes. The first type included compounds with two or four attached receptors in the upper part of the molecule, the second in the lower part of the molecule. The remaining several types included combinations of the first two. After a detailed analysis of the chemical properties of each type of compound, the scientists revealed differences in their behavior and properties.
So, for example, when two specific groups are inserted in the lower part of the molecule, it begins to more efficiently bind adenosine diphosphoric acid (ADA) - a compound formed during the partial decomposition of ATA.

“Over the past two decades, many research groups have paid great attention to the synthesis of host molecules with high affinity for biologically important substances. Among these methods, the recognition and transfer of nucleotides — adenosine diphosphoric and adenosine triphosphoric acids — is of particular importance due to their great biological significance. Adenine-containing nucleotides are important as a universal source of energy and as intracellular mediators in many biological processes. For the first time, we created molecules based on calixarenes that can recognize ATA and ADA in a solution and bind to them at low concentrations ”says Viktor Khrustalyov, one of the authors of the work, doctor of chemical sciences, head of the inorganic chemistry department of the RUDN University.

Main Publications View all
15 Nov 2017
RUDN University scientists publish results of their scientific researches in highly-recognized in whole world and indexed in international databases journals (Web of Science, Scopus ect.). That, of course, corresponds to the high status of the University and its international recognition. Publications of June-September 2017 ( In Journals of categories Q1-Q3)
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International scientific cooperation View all
03 Nov 2017
The main goal of the RUDN University and UNISDR Office for Northeast Asia and Global Education and Training Institute for Disaster Risk Reduction at Incheon (UNISDR ONEA-GETI) cooperation is to obtain knowledge about disaster risk reduction and international experience in this area for creating training courses for basic and additional professional education in RUDN
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30 Dec
Biologists from RUDN University discovered the secret of flaxseed oil with long shelf life

Biologists from RUDN University working together with their colleagues from the Institute of Molecular Biology of the Russian Academy of Sciences and the Institute of Flax studied the genes that determine the fatty acid composition in flaxseed oil and identified polymorphisms in six of them. The team also found out what gene variations could extend the shelf life of flaxseed oil. This data can be used to improve the genetic selection of new flax breeds. The results were published in the BMC Plant Biology journal.

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11 Oct
Mowing Is More Harmful to Soil Than Grazing

A team of biologists analyzed soil samples from a pasture and a regularly mowed meadow and found out that grazing lets more carbon get into the soil than mowing. This, in turn, improves the carbon cycle and makes microorganisms more efficient.

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11 Oct
Soil scientists suggest method for remediating urban garden soils contaminated with lead and arsenic

The soils of urban gardens and vegetable patches contain a lot of toxicants (including lead and arsenic) in high concentrations which can be harmful to the health of children and people with chronic diseases. A team of soil scientists from RUDN University suggested a remediation method developed based on data collected in a garden of Brooklyn (NY, U.S.).

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