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Researchers conducted a systematic review of articles that analyzed the effect of medicine remedies used to treat COVID-19 during pregnancy.

Researchers conducted a systematic review of articles that analyzed the effect of medicine remedies used to treat COVID-19 during pregnancy.

RUDN physician Anna Borisova, in collaboration with colleagues from Italy, used effective searches and classified 123 articles on this research topic. A literature review was conducted by searching databases of medical and biological publications: PubMed, the U.S. National Library of Medicine, and Embase (Elsevier), a biomedical database.

Researchers conducted a search between 1st of January and 5th of May, 2020, using the keywords “COVID-19,” “SARS-CoV-2,” “pregnancy,” and “therapy.” The analysis covered only drugs with presumptive effects on COVID-19 whose safe use during pregnancy has been proven by clinical trials in other infectious diseases. Drugs contraindicated in pregnancy or with unknown side effects were not included in this review.

“Pregnant women are a high-risk group for coronavirus complications. The situation is also complicated by the fact that not all medications can be prescribed to pregnant women due to their possible teratogenic effect on the fetus, which poses new challenges for the development of effective and safe medications for this category of COVID-19 patients”, — Anna Borisova, Ph.D. in Medicine, assistant of the Department of Obstetrics and Gynecology, Institute of Medicine, RUDN.

As a result of the study, scientists identified groups of drugs that can be used to treat COVID-19 during pregnancy, as well as indications for their prescription:

  • Antiviral medications: lopinavir, ritonavir, remdesivir.
  • Antimalarial medications: hydroxychloroquine.
  • Anticoagulants medications: Low-molecular-weight heparin (due to increased risk of thromboembolic complications in patients with COVID-19).
  • Steroids medications: betamethasone (to accelerate fetal lung maturation, since SARS-CoV-2 infection during pregnancy, especially in the third trimester, may increase the risk of premature rupture of fetal membranes and premature birth).
  • Antibacterials medications: amoxicillin, azithromycin, ceftriaxone (must be prescribed only if a bacterial infection is suspected).
  • Metformin and statins (can be used as adjuvant therapy, to reduce the required dose of antiviral medication and, therefore, its side effects).
  • Reconvalescent plasma (antibodies contained in the plasma of convalescents reduce the viral load, the severity of the disease, and improve aeration).
  • Immunomodulators medications, such as tocilizumab.
  • Interferon type I.
Main Publications View all
15 Nov 2017
RUDN University scientists publish results of their scientific researches in highly-recognized in whole world and indexed in international databases journals (Web of Science, Scopus ect.). That, of course, corresponds to the high status of the University and its international recognition. Publications of June-September 2017 ( In Journals of categories Q1-Q3)
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Scientific Conferences View all
03 Nov 2017
RUDN University organized the first 5G Summit R&D Russia on June 19 - 20, 2017
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30 Dec
Biologists from RUDN University discovered the secret of flaxseed oil with long shelf life

Biologists from RUDN University working together with their colleagues from the Institute of Molecular Biology of the Russian Academy of Sciences and the Institute of Flax studied the genes that determine the fatty acid composition in flaxseed oil and identified polymorphisms in six of them. The team also found out what gene variations could extend the shelf life of flaxseed oil. This data can be used to improve the genetic selection of new flax breeds. The results were published in the BMC Plant Biology journal.

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11 Oct
Mowing Is More Harmful to Soil Than Grazing

A team of biologists analyzed soil samples from a pasture and a regularly mowed meadow and found out that grazing lets more carbon get into the soil than mowing. This, in turn, improves the carbon cycle and makes microorganisms more efficient.

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11 Oct
Soil scientists suggest method for remediating urban garden soils contaminated with lead and arsenic

The soils of urban gardens and vegetable patches contain a lot of toxicants (including lead and arsenic) in high concentrations which can be harmful to the health of children and people with chronic diseases. A team of soil scientists from RUDN University suggested a remediation method developed based on data collected in a garden of Brooklyn (NY, U.S.).

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