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RUDN chemist, along with colleagues from the RAS Institutes, simplified the synthesis of antitumor compounds

RUDN chemist, along with colleagues from the RAS Institutes, simplified the synthesis of antitumor compounds

A RUDN chemist in collaboration with colleagues from N.D. Zelinsky Institute of Organic Chemistry and N.K. Koltsov Institute of Developmental Biology (IDB), RAS have developed a new method for the synthesis of isoxazole derivatives — substances that destabilize the process of cell division and potentially may become the basis for new anti-cancer drugs. The new method is based on the use of easily available reagents and does not require high temperatures.

Many modern anticancer drugs are toxic, difficult to access and/or very expensive. Moreover, tumor cells may develop resistance to the drugs used. Therefore, researchers study the biological properties of molecules in order to obtain new antitumor drugs with optimal properties. One of the common approaches to the search for such drugs is testing of analogues of substances that already showed antitumor activity. Such substances include, in particular, isoxazole derivatives that inhibit — “turn off” — the Hsp90 protein, which is necessary for the survival of tumor cells. However, compounds of this class are inaccessible due to the complexity of the synthesis procedure, which requires, in particular, the complete absence of water molecules, and the reagents are expensive and toxic.

RUDN chemist Viktor Khrustalev and his colleagues developed a method for the synthesis of isomers of these substances, that is, the compounds that are identical in atomic composition but different in the arrangement of atoms in space. Easily accessible derivatives of arylnitromethanes and chloroacetamides were used as raw materials, and the reaction itself was carried out at temperatures not exceeding 80 degrees at atmospheric pressure and did not require anhydrous conditions.

The obtained substances had anticancer activity, but unlike the prototype compounds, they did not inhibit Hsp90 protein. Their mechanism of action is based on the destabilization of the cell division process as they prevent the formation of microtubules, which are important in the process of cell division.

Taxol derivatives, one of the most commonly used antitumor agents, have the same mechanism of action. Basing on the compounds obtained by the scientists, it is possible to create a substitute for an expensive, inaccessible and highly toxic derivatives of taxol in the treatment of cancer.

The work was published in European Journal of Organic Chemistry. 

Visiting Professors View all
03 Nov 2017
Michele Pagano is a graduate of the University of Pisa, a leading scientist, the author of more than 200 publications in international journals, and a participant in many international research projects
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RUDN University scientists publish results of their scientific researches in highly-recognized in whole world and indexed in international databases journals (Web of Science, Scopus ect.). That, of course, corresponds to the high status of the University and its international recognition. Publications of June-September 2017 ( In Journals of categories Q1-Q3)
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Every year, RUDN University selects the best of the best in the field of science and innovation and encourages with a special reward. Since 2009, the Academic Council of the University has been awarding one reward in natural and technical sciences and the other one in social and humanitarian sciences. Both individual researchers and groups of authors can become laureates.

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“Science is the basis of all progress that facilitates the life of mankind and reduces its suffering,” — Marie Sklodowska—Curie. A symbol of a woman’s success in science. The first scientist in the world — twice winner of the Nobel Prize.

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