3
RUDN University Chemists obtained coenzyme from Parsley and Dill seeds

RUDN University Chemists obtained coenzyme from Parsley and Dill seeds

Scientists from RUDN University have developed a new method for converting planthydrocarbon radicals into substances that canbe used to synthesize coenzyme Q0.

Coenzymes of the Q group in mammals and plants are responsible for maintaining the energy metabolism of cells. They are powerful antioxidants and regulate the permeability ofmitochondrial membranes. Coenzyme Q0 is known to reduce and even suppress metastasis in breast, skin and ovarian cancers.

“We proposed a simple way to obtain the necessary element for the synthesis of Q0 precursors based on allylpolymethoxybenzenes. It is easy to isolate them in large quantities from parsley and dill extract,” says RUDN scientist Viktor Khrustalev.

The main stage on the way of obtaining a coenzyme is hydrogenation to allylpolymethoxybenzenes fragments. This process takes place in a special apparatus with a fluoroplastic insert using aporous palladium catalyst. After use, the reaction mixture is separated from the catalyst without additional filters.

The minimum reaction time is 4 to 8 hours. However, with an increased hydrogen pressure,the reaction takes 2-4 hours. Even with accelerated production, no methylbenzene by-products remain after hydrogenation, which simplifies further purification. The catalyst canthen be used up to 40 times.

"With the help of X-ray diffraction analysis, we have confirmed the spatial structure of there sulting compound. This allows further study of its antitumor and antioxidant properties,"explained Viktor Khrustalev, Doctor of Chemistry, Head of the Department of Inorganic Chemistry of the Peoples’ Friendship University of Russia.

Mendeleev Comunications 

Main Publications View all
15 Nov 2017
RUDN University scientists publish results of their scientific researches in highly-recognized in whole world and indexed in international databases journals (Web of Science, Scopus ect.). That, of course, corresponds to the high status of the University and its international recognition. Publications of June-September 2017 ( In Journals of categories Q1-Q3)
1309
International Projects View all
Similar newsletter View all
15 Jul
RUDN physicians have identified genetic characteristics that may affect the predisposition to re-stenosis

RUDN University physicians have identified genetic characteristics that may affect the predisposition to re-stenosis — narrowing of the lumen of the vessel — after the installation of a stent. The results will help to determine the risk of restenosis and select personalized therapy more accurately.

28
15 Jul
RUDN Chemists Have Created a Reusable Switch Catalyst for The Synthesis of Two Different Compounds

RUDN chemists have created a reusable catalyst for the oxidation of sulfides for the synthesis of drugs, dyes, and other compounds. It can “switch” the final product and provides “green” reaction conditions.

40
15 Jul
Scientists Report New Hydrogel to Protect Wounds from Germs

RUDN University and Shahid Beheshti University (SBU) chemist together with colleagues from Iran created a hydrogel film for wound dressing. It protects the wound from germs and is harmless to healthy tissues. Moreover, its porous structure can hold antibiotic, which kills dangerous microorganisms and provide additional protection.

20
Similar newsletter View all