RUDN scientists developed biocompatible nanothermometers without the use of rare earth elements
The new biomaterial will enable precise temperature monitoring during surgeries, diagnose inflammatory processes and be used in the development of other smart biomaterials.
“A new class of MOF-materials was synthesized based on zinc ions (biocompatible metal), organic ligand H₄TBAPy using innovative topological design (2D and 3D structures). The synthesized porous crystal structures have a record sensitivity of up to 2.12% K-¹, a wide temperature range of
7-300 K (-266 °C to +27 °C), and full biocompatibility. The possibility of real-time visualization and tracking is also incorporated,” — Alexander Novikov, researcher at RUDN Joint Institute for Chemical Research.
The advantage of the developed highly sensitive nanothermometers over analogs is as follows:
- Do not contain rare earth elements.
- Possess an optimal porous structure due to the topological design.
- Both 2D and 3D configurations can be created.
“To test the efficacy of MOF nanoparticles, we injected them intracardiacally and through the digestive system into transparent Casper fish. The experiment demonstrated 100% survival rate of the organism after the introduction of the substance, which indicates the absence of toxicity and is confirmed by MTT tests and immunohistochemistry. Also, the drug allowed us to accurately measure the temperature of internal organs — the color of luminescence changed from green to blue when cooling from 30 to 0 °C, which allowed us to monitor the temperature of organs in vivo,” — Alexander Novikov, researcher at RUDN Joint Institute for Chemical Research.
The results are published in Advanced Functional magazine.
The RUDN University Science and Innovation Prize winners were honoured at the extended meeting of the Academic Council. In 2024 the terms of the traditional RUDN University Prize were changed: for the first time the competition was announced in two categories: leading scientists and young scientists.
According to the International Energy Agency (IEA), electricity consumption in Africa has increased by more than 100% over the past two years (2020-2022). However, 74.9% of this energy is still produced by burning organic fuels — natural gas, coal and oil. At the same time, the level of electrification on the continent remains extremely low — only 24%, while in other developing countries it reaches 40%. Even in grid-connected areas, electricity supply is often unreliable: industrial enterprises lose energy on an average of 56 days a year.
Today, diagnosis and treatment planning with orthodontists takes several days. Also, complications can arise during treatment that slow down the patient's recovery process. For example, improper orthodontic treatment planning can lead to temporomandibular joint dysfunction.
The RUDN University Science and Innovation Prize winners were honoured at the extended meeting of the Academic Council. In 2024 the terms of the traditional RUDN University Prize were changed: for the first time the competition was announced in two categories: leading scientists and young scientists.
According to the International Energy Agency (IEA), electricity consumption in Africa has increased by more than 100% over the past two years (2020-2022). However, 74.9% of this energy is still produced by burning organic fuels — natural gas, coal and oil. At the same time, the level of electrification on the continent remains extremely low — only 24%, while in other developing countries it reaches 40%. Even in grid-connected areas, electricity supply is often unreliable: industrial enterprises lose energy on an average of 56 days a year.
Today, diagnosis and treatment planning with orthodontists takes several days. Also, complications can arise during treatment that slow down the patient's recovery process. For example, improper orthodontic treatment planning can lead to temporomandibular joint dysfunction.