Events

A novel synthetic strategy based on 1,3-dipolar cycloaddition of a-metalated isocyanides to double bond of different enamines and enaminones represent a direct, simple and effective approach to 2,4-substituted pyrroles from common and commercial available starting materials. We found that potassium tert-butoxide is a unique base which can be used for this type of cycloaddition. The new pyrroles were formed in good-to-excellent yields.

A novel synthetic strategy based on 1,3-dipolar cycloaddition of a-metalated isocyanides to double bond of different enamines and enaminones represent a direct, simple and effective approach to 2,4-substituted pyrroles from common and commercial available starting materials. We found that potassium tert-butoxide is a unique base which can be used for this type of cycloaddition. The new pyrroles were formed in good-to-excellent yields.

The heterocyclic pyrollidine rings are very common in natural products and are the leading components of alkaloids.(1) They are important synthetic components of HIV reverse transcriptase enzyme and inhibitors of substance P neurotransmitters.(2,3)

The present study was focused to understand the binding interaction mechanism of, a newly synthesized 1-imino-1,2-dihydropyrazino[1,2-a]indol-3(4H)-one compound in bovine serum albumin and 5-hydroxytryptamine receptor 1B using molecular docking and molecular dynamics simulation studies.

Prussian Blue type nanoparticles are exciting nano-objects that combine the advantages of molecule-based materials and nanochemistry. They are made by transition metal ions or lanthanides assembled through cyano-bridged ligand into nano-sized architectures of the general formula AxMyII[M’III(CN)6]z (where A is a monovalent cation, MII and M’III are transition metal ions or lanthanides). These nano-objects attracted a great deal of interest during the last ten years due to their specific molecule-based nature that is different compared to other inorganic nanoparticles. This lecture will provide a brief critical look on the recent advancement in this field of research focalising on the design of PB type nano-objects and their nanocomposites promising as nanoprobes for imaging, as therapeutic agents for photothermal therapy, as well as agents for Cs+ decontamination.

Coordination chemistry of lanthanide ions allows the tailored design of multifunctional ferroelectric molecule-based materials where the properties are gathered into a single molecular system. We investigate here, by using luminescent and magnetically anisotropic lanthanides ions assembled with an enantiopure antenna ligand, the synthesis of high temperature ferroelectric complexes having a high degree of functionality, combining Single-Molecule Magnet behavior, optical activity and lanthanide luminescence. Remarkably, these molecular systems behave as ferroelectrics up to a temperature above 180 K of the Curie temperature of BaTiO3, making it the highest temperature working molecular ferroelectric yet reported. Remarkably, investigation of the magnetoelectrical coupling at room temperature confirms their great potential as multiferroics.

The nitrogen heterocycle presents a very important use in the pharmaceutical and agrochemicals synthesis. In this case the substituted tetrahydroisoquinoline has a broad range of biologicals activities.