Events and Invitations
Events
Scientific seminar of post-doc Gaddam Krishna «First Total Synthesis of Furanocembranoid-1»
Isolation and medicinal importance: In 2007, Khanitha Pudhom et al. isolated a class of furanocembranoids1 1 (Figure 1) from the hexane extract of croton oblengifolius roxb sp. Furanocembranoids-1 showed cytotoxicities againest BT474 (human breast ductol carcinoma), CHAGO (human undifferentiate lung carcinoma), Hep-G2 (human liver hepatoblastoma), KATO-3 (human gastric carcinoma) and SW-6 (human colon adrenocarcinoma).
Scientific seminar of post-doc Kletskov A.V. « Novel small macrocycles on the basis of bis-furfurylsulfamides»
The constant growth of interest in different macrocycles can be mainly explained by their broad scope of possible applications. Macrocycles were proven to be valuable bioactive substances and complexing agents.
Scientific seminar of post-doc Efimov I.V. «Novel and convenient route toward 2,4-disubstituted pyrroles based on the reaction of enaminones and isocyanides»
Pyrrole core is the basis of many pharmacologically active compounds1,2. For example, 3-substituted pyrroles are found in a variety of medicinal and agrochemical applications, such as efficient inhibitors of histone deacetylase3, HIV-1 transcriptase4, and COX-1/COX-2 cyclooxygenases5. Furthermore, the 4-acetyl pyrroles (JWH series) has moderate affinity for the CB1 receptor6.
Scientific seminar of post-doc S. Cherukupalli «Design and synthesis of novel pyrrole analogues from imidazolines as anticancer agents»
Heterocycles hold a key point in organic and medicinal chemistry as they act as a bridge between life sciences and biochemical investigations. A significant amount of contemporary investigation is being currently pursued on these compounds worldwide.