Events

Topic: On the asymptotic behavior of solution to the Cauchy problem for parabolic equations. Above estimates, lower estimates, stabilization rates.

Isolation and medicinal importance: In 2007, Khanitha Pudhom et al. isolated a class of furanocembranoids1 1 (Figure 1) from the hexane extract of croton oblengifolius roxb sp. Furanocembranoids-1 showed cytotoxicities againest BT474 (human breast ductol carcinoma), CHAGO (human undifferentiate lung carcinoma), Hep-G2 (human liver hepatoblastoma), KATO-3 (human gastric carcinoma) and SW-6 (human colon adrenocarcinoma).

The constant growth of interest in different macrocycles can be mainly explained by their broad scope of possible applications. Macrocycles were proven to be valuable bioactive substances and complexing agents.

Pyrrole core is the basis of many pharmacologically active compounds1,2. For example, 3-substituted pyrroles are found in a variety of medicinal and agrochemical applications, such as efficient inhibitors of histone deacetylase3, HIV-1 transcriptase4, and COX-1/COX-2 cyclooxygenases5. Furthermore, the 4-acetyl pyrroles (JWH series) has moderate affinity for the CB1 receptor6.

Heterocycles hold a key point in organic and medicinal chemistry as they act as a bridge between life sciences and biochemical investigations. A significant amount of contemporary investigation is being currently pursued on these compounds worldwide.