RUDN Medics Identified an Error in the Therapy of Ischemic Stroke After-Effects
An ischemic stroke can lead to death, disability, cerebral edema, alteration of consciousness, and other complications that considerably affect the quality of the patients’ lives. The method of selective cerebral hypothermia is used to treat cerebral edema and reduce intracranial pressure. According to RUDN medics, some treatment standards included into this method are incorrect.
In the course of selective cerebral hypothermia the brain cortex is cooled off causing the body’s activity to slow down and relieving the edema. This effect is reached using a special helmet with 0-8℃ liquid circulating inside it. The method also slows down the metabolism, and the patients need to make adjustments to their diets for the period of therapy. Previously, the patients were expected to get 20-25 Kcal per 1 kilogram of body weight. For an average weight person this means about 1,600 Kcal a day - two times less than it is required by healthy people. RUDN medics demonstrated that these values were incorrect. In fact, the amount of calories should be reduced by 15-20%.
The researchers divided 27 ischemic stroke patients from 53 to 80 years old into two groups. The first one was treated using the selective cerebral hypothermia method, and the other one - without it. All other therapy aspects were the same in both groups. The diet of the patients was developed in view of their energy consumption and daily protein loss. The first group showed positive dynamics 24 hours after the beginning of the treatment, and the second one - none at all. After the patients in the first group underwent selective cerebral hypothermia, all their health indicators went back to normal. As a result, the scientists demonstrated that standard dietary recommendations for such patients had little efficiency and recommended reducing the dosage by 15-20%.
“The neuroprotective effect of therapeutic hypothermia has already been acknowledged all over the world. However, we have to continue clinical studies and optimize the therapy. We provided new recommendations regarding calorie value reduction in case of hypothermia. Currently, they are only preliminary, but one may expect our method to reduce the morality and disablement rate in the patients with ischemic stroke,” said Oleg Shevelev, Professor of V.A. Frolov Department of General Pathology and Pathological Physiology at RUDN.
Bacteria in biofilms are 1,000 times more resistant to antibiotics, disinfectants, mechanical treatment, and other types of stress. A chemist from RUDN University suggested a method to prevent the formation of biofilms and reduce the resistance of bacteria to antimicrobial medications. This might help increase the efficiency of antibacterial treatment in the food industry, medicine, and agriculture.
A specialist in spacecraft movement control analyzed the process of placing vehicle stages, boosters, and other space debris into the so-called disposal orbit and suggested cleaning lower orbits up with a spacecraft that has modules with engine units on board. These modules will attach to space debris objects and move them away. As for the geostationary orbit, a preferable way to clean it up would be a towing spacecraft that transports space debris objects into the disposal orbit.
A biologist from RUDN University studied the development of the immune response in prepubertal male and female animals. According to her, the severity and mortality of infectious and inflammatory diseases at this age depend not on the sex hormones, but mainly on the chromosome set or karyotype.