Water under low deuterium concentrations proved to be useful for medicine

Water under low deuterium concentrations proved to be useful for medicine

RUDN scientists explored how reduction of deuterium in water influences reactions in living organisms. As was found that reactions went in less time comparing to those when deuterium was changed into hydrogen. The article was published in Chemical Engineering Journal.

Deuterium, heavy hydrogen isotope, having a nuclear containing an odd neutron, is present in any kind of natural origin water. In typical drinking water rate of deuterium does not exceed 0,015%. If the concentration of deuterium changes to higher or lower level, biological characteristics of water will change. For example, results of previous research show that water with deuterium insufficiency may produce antitumor, antidotal, and metabolical action, influence vital signs of cell cultures in water environment.

The group of RUDN scientists under the guidance of Anton Syroeshkin and Igor Zlatskiy, a Department of Pharmaceutical and Toxicological Chemistry of RUDN Medical Institute explored how the change in deuterium concentration in water influences the processes in biological molecules and vital cells.

Scientists compared water with different isotope rations: light water with reduced deuterium content (D/H around 5 ppm), water with normal deuterium content(140 ppm), and heavy water D2O.

For molecular level of life arrangement, the scientists of RUDN explored galactose mutarotation - rotary transformation of molecule, supramolecular – enzymatic destabilaso-lysozyme activity, for pharmaceutical substances - solubility and diphase distribution, and life time of vital cells in water with different isotope composition.

It was found that rate constant of speed variation of optical rotate for L-galactose was two times smaller than for D- galactose with small content of deuterium despite the concentration. While in heavy water first order mutarotation for L-galactose was not noticed.

The initial velocity of enzymatic lysozyme activity of destabilaso-lysozyme changed: in water under low content deuterium it raised twice, while in heavy water there was no change in activity.

When exploring suspension systems the dissolution rate of active drug substances was investigated. Dissolution occurs faster when protium concentration is greater than deuterium. It is in line with the normal kinetic isotope effect and proves the importance of right choice of solvent isotope composition to speed the process.

The change in water isotope composition influenced the life cells behavior: ambigua single-cells organisms were immobilized up to 8 times faster in water solutions under low deuterium concentrations.

These findings may prove useful for the following biomedical and therapeutic research, where deuterium can act as a regulator of biological characteristics of normal or tumor cells.

The article in Chemical Engineering Journal

News
All news
Science
20 Sep
RUDN University mathematician determined the conditions for the coexistence of three species in the wild

RUDN University mathematician together with colleagues from India and France for the first time studied in detail the system of coexistence of three species of living creatures in the wild. The results help to understand what parameters determine the extinction andли survivalof species, and how the number of species changes in space and time.

Science
15 Sep
RUDN University Chemist Created Coordination Polymers Films with up to 99.99% antibacterial efficiency

RUDN University chemist with his colleagues from Portugal has developed two types of coating based on new coordination polymers with silver. Both compounds were successfully tested against four common pathogens.

Science
12 Sep
RUDN scientists have improved titanium dental implants with graphene nanosloyers

RUDN researchers have created and tested a method for processing titanium dental implants. It turned out that theanoslos of graphene on the surface of titanium improve its interaction with stem cells,which are placed on the implant so that it better "takes root".Thanks to this method ofprocessing, stem cells are better kept on the surface, multiply and turn into the desired cells.