Electromechanical Model of Cardiac Muscle Tissue with Mechano-Electrical Feedback

Electromechanical Model of Cardiac Muscle Tissue with Mechano-Electrical Feedback

On 12th of March 2020 one of the leading experts of RUDN Research Center Mathematical Modelling in Biomedicine Fyodor A. Syomin held an open lecture Electromechanical Model of Cardiac Muscle Tissue with Mechano-Electrical Feedback

Many heart diseases are associated with arrhythmias of various nature. For a deeper understanding of the causes of arrhythmias formation and conditions of their persistence, as well as for the development of accurate personalized models that could be applied in medical practice, a detailed model of myocardial electromechanics is needed. Such a model should consider the interconnections of processes of various nature, and, if possible, be quite simple from a computational point of view. RUDN mathematicians present a prototype of the electromechanical model of the myocardium, in which the description of the electrical activation of the cardiac muscle by a simple Aliev-Panfilov model is coupled with a new model of myocardial mechanics developed by the group of the report author. The simulation results for the appearance and propagation of spiral waves of the action potential in deformable myocardium are shown. The effects of mechano-electrical feedback taken into account and introduced at the levels of the cell and tissue are demonstrated.

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