RUDN University biologist found that Chinese date improves the immune system of fish
Click chemistry methods are used to synthesize libraries of substances with high chemical diversity, which is important when developing new drugs. These reactions are necessary for introduction of labels (for example, fluorescent ones) into biological macromolecules, proteins, and DNA molecules. This is used in biological and medical research.
The most commonly used click chemistry reaction is the addition of a substance that contains a carbon-carbon triple bond (alkine) to a compound containing a fragment with three nitrogen atoms in a row (azide). The classic version of the reaction involves the use of copper in oxidation state (I) as a catalyst. For this, ions of copper (II) and an excess of a reducing agent are introduced into the reaction, or copper (I) is used and the reaction is conducted with protection against oxygen, which imposes certain restrictions on the application of this reaction.
A chemist from RUDN University Rafael Luque and his colleagues have developed a series of catalysts with copper ions attached to the surface of silica gel particles using cyclic cyclodextrin oligosaccharide. Cyclodextrin consists of seven glucose molecules closed in a cycle. Inside the cycle there is a container that can hold the copper ion and increase its catalytic activity. Ultrasound irradiation was used to facilitate the binding of cyclodextrin to the surface of silica gel.
The effectiveness of the created catalysts was evaluated on a model reaction of phenylacetylene with benzylazide. The researchers managed to achieve a yield of the reaction product of more than 99%. The yield with copper (II) acetate was 14%, and in the case of copper (II) sulfate, the reaction did not occur at all. The method for producing the catalyst is simple, safe for the environment, and cheap; its use does not require to add reducing agents or oxygen-free conditions. The catalysts can find application in the pharmaceutical industry and in biomedical research.
The paper was published in the journal Molecules.
On October 4, the Research and Educational Resource Center (REC) of innovative technologies of immunophenotyping, digital spatial profiling and ultrastructural analysis (molecular morphology) opened at the RUDN.
RUDN University scientists conducted a comprehensive soil and environmental survey and took more than 80 soil samples in Zaryadye Park. An assessment of the physicochemical, microbiological, and ecotoxicological properties of soils made it possible to develop recommendations and a plan for the care of soils in analogous landscapes in the park.
RUDN University chemist with colleagues from India and Korea created a nanofilter for water purification from synthetic dyes. The graphene-based composite can quickly remove up to 100% of harmful compounds from water, and it can be used up to seven times without losing efficiency. In addition, the synthesis of the nanofilter itself is economical and environmentally friendly.
On October 4, the Research and Educational Resource Center (REC) of innovative technologies of immunophenotyping, digital spatial profiling and ultrastructural analysis (molecular morphology) opened at the RUDN.
RUDN University scientists conducted a comprehensive soil and environmental survey and took more than 80 soil samples in Zaryadye Park. An assessment of the physicochemical, microbiological, and ecotoxicological properties of soils made it possible to develop recommendations and a plan for the care of soils in analogous landscapes in the park.
RUDN University chemist with colleagues from India and Korea created a nanofilter for water purification from synthetic dyes. The graphene-based composite can quickly remove up to 100% of harmful compounds from water, and it can be used up to seven times without losing efficiency. In addition, the synthesis of the nanofilter itself is economical and environmentally friendly.