RUDN University chemist created an effective catalyst for the synthesis of organic sulfides

RUDN University chemist created an effective catalyst for the synthesis of organic sulfides

RUDN University received a new compound — a molybdenum complex with a phosphate “bridge” in the form of a dumbbell. The complex accelerates the formation of sulfides from oxides and can be used in the production of medicines and cosmetic materials.

The reduction reaction of organic sulfides from oxides, or deoxygenation of sulfoxides, is a simple direct process of splitting oxygen from organic oxide to produce sulfide. This reaction is important because it occurs in biological processes and in the synthesis of many organic compounds. Organic sulfides are present in most antibiotics, medications, and biological compounds. Sulfides are key intermediates of organic synthesis and important components of many fine chemicals, such as perfumes and cosmetics. Living organisms use an enzyme containing a molybdenum-containing complex to accelerate the reduction of sulfoxides. Molybdenum — based compounds are successfully used in the production of not only synthetic sulfides, but also other classes of important organic compounds-phosphines, olefins. The synthesis of new molybdenum catalysts with improved characteristics based on fundamental knowledge about the mechanisms of deoxygenation is an important and urgent task.

“Modern synthetic chemist, the architect and the Builder. Knowing the properties of building materials — fragments of molecules, it first simulates the structure of a complex molecule, and then collects it. In this work, we were able to obtain a new molybdenum complex in the form of a dumbbell,” the authors of the publication write.

The molybdenum complex was synthesized under hydrothermal conditions (in water and under heating) using salts of molybdenum acid and a number of phosphonic acids that can be converted to phosphate ions. using modern modeling and structural analysis methods, it was possible to classify and accurately determine the structure of a new compound — an eight-core molybdenum cluster, in which four molybdenum cores from below and four from above are connected by a phosphate bridge and additionally stabilized by hydroxyl groups and ammonium ions.

The resulting complex was effective as a homogeneous catalyst in the reduction of diphenyl sulfoxide to diphenyl sulfide. The reaction used a cheap and eco-friendly reducing agent pinacol. By varying various synthesis conditions (duration, temperature, type of solvent, amount of catalyst), chemists were able to achieve a product yield of 99 %. The complex after heat treatment at 310 oC showed another important property — high proton conductivity. Thus, it can be used in obtaining functional membrane materials for creating electrochemical devices — sensors, fuel cells, and supercapacitors.

“After such a remarkable result in the diphenyl sulfide reduction reaction, we tested a catalyst in the reduction of other complex organic sulfides. And we were pleasantly surprised — the yields of the corresponding oxides are also high. The catalyst can be used in the synthesis of even more different substances. In the future, we plan to test this catalyst in other catalytic transformations,” the authors conclude.

Article in the journal of Inorganic Chemistry.

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03 Nov 2017
Michele Pagano is a graduate of the University of Pisa, a leading scientist, the author of more than 200 publications in international journals, and a participant in many international research projects
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RUDN University scientists publish results of their scientific researches in highly-recognized in whole world and indexed in international databases journals (Web of Science, Scopus ect.). That, of course, corresponds to the high status of the University and its international recognition. Publications of June-September 2017 ( In Journals of categories Q1-Q3)
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