2
RUDN University Pediatricians found a link between bronchial asthma and arrhythmia in children

RUDN University Pediatricians found a link between bronchial asthma and arrhythmia in children

RUDN University Pediatric cardiologists studied the mechanism of development of complications from the cardiovascular system in patients with bronchial asthma. It turned out that the narrowing of the bronchi can lead to dangerous disorders of the heart from an early age.

Bronchial asthma is a chronic inflammatory disease of the respiratory tract, in which the smooth muscles of the bronchi contract, and they themselves narrow, making it difficult for the patient to breathe. It is not possible to get rid of it once and for all, so therapy consists in controlling the symptoms, and the patient is recommended to avoid risk factors. Additional pathologies may prevent doctors from taking the manifestations of bronchial asthma under control. This, in turn, provokes the development of complications and concomitant disorders. Due to excessive stretching of the atrial wall, patients develop supraventricular arrhythmia — a violation of the rhythm of contractions of the heart muscle. This pattern was found in several studies in adults, and RUDN University doctors first studied it in children.

"To date, the indications of an electrocardiogram with bronchial asthma in children have not been sufficiently studied. The relationship between the features of the supraventricular component of the ECG and the patency of the bronchi, which would allow us to determine changes in the heart muscle and heart rhythm disorders in children in order to predict the development of such complications of bronchial asthma, is not described in the scientific literature," Dmitry Ovsyannikov, MD, Head of the Department of Pediatrics, RUDN University.

To search for signs of future arrhythmia, doctors studied atrioventricular conduction, as well as ECG readings. The state of the bronchi was assessed according to spirometry — speed and volume indicators of respiration. The study involved 103 patients of the Nizhny Novgorod City Clinical Hospital aged 6-17 years. At the same time, children with hypoxia, that is, with blood oxygen saturation below 98%, were excluded. According to the results of measurements, children and adolescents were divided into three groups depending on their Tiffno index — the ratio of the volume of forced exhalation to the functional vital volume of the lungs, expressed as a percentage. This indicator was supposed to demonstrate how asthma and bronchial spasms make it difficult for the subjects to breathe. The first group included 15 children with a Tiffno index of more than 85%, the second — 40 people with an index of 75-85%, the third — 48 patients with indicators below 75%.

In the ECG data, pediatricians were most interested in the PQ interval — the area between the teeth of the same name on the cardiogram. It reflects the passage of an electric pulse of excitation of the heart muscle through the atrium and further into the ventricles. The length of the PQ interval in children is normally within 0.12-0.16 seconds, in adolescents it can reach 0.18 seconds. In the subjects of the first and second groups, the length of this section on the cardiogram was 0.01-0.02 seconds less than in the third. The rPQ coefficient — the value of the length of the PQ interval of patients in relation to accepted medical standards — consistently increased with a decrease in the Tiffno index. Thus, children who showed obstruction and a decrease in bronchial patency, which was seen by an index of less than 75%, had prerequisites for the development of arrhythmia.

"With a decrease in the Tiffno index, there was a statistically significant increase in the length of the PQ interval and the rPQ coefficient, which indicates a slowdown in the passage of impulses from the atria to the ventricles with narrowing of the bronchi. Our results should not be ignored, since in adults with bronchial asthma, the disease can progress and be accompanied by arrhythmias, including severe and even fatal cases. The study should be repeated on a larger sample and supplemented with long-term observations of ECG and spirometry parameters," Dmitry Ovsyannikov, MD, Head of the Department of Pediatrics, RUDN University.

The results are published in the journal Frontiers in Pediatrics.

International scientific cooperation View all
12 Dec 2024
From 19 to 23 November 2024, RUDN hosted the III International Scientific Conference ‘For the Sustainable Development of Civilisation: Cooperation, Science, Education, Technology’. The event gathered more than 2000 participants from 72 countries.
172
Scientific Conferences View all
12 Dec 2024
About 200 participants from Russia and 20 countries met at the National Interdisciplinary Scientific Seminar with International Participation “Law in Medicine. Medicine in Law: Points of Contact”. The subject was “Happy Motherhood: unsolved problems of obstetrics, gynaecology and perinatology”.
138
Similar newsletter View all
20 Apr
A volunteer of the Red Army and head of the veterinary medicine course — Matilda Mityaeva's combat and scientific path

Matilda Pavlovna Mityaeva was born in 1925. In November 1942, she volunteered for frontline duty. She participated in the Great Patriotic War from November 1942 to June 1945 as part of the 53rd Infantry Division of the 475th Infantry Regiment. She was wounded twice.

24
20 Apr
RUDN University Team – the 1st place in the all-russian competitive selection of scientific projects “Technologies for human health”

The team led by Sergey Zyryanov, Head of the Department of General and Clinical Pharmacology, became the winner of the All-Russian competition of scientific projects "Technologies for Human Health".

32
20 Apr
RUDN University Scientific Agenda to 2030: New Programme for R&D and Innovation Activities Development

RUDN University constantly adapts to the changes of the modern world and responds to challenges flexibly. This allows us to keep the standard of a world-class research university. The sphere of science is no exception. Peter Dokukin, Head of the Research Division, presented the updated R&D Programme at the meeting of the RUDN University Academic Council.

23
Similar newsletter View all