RUDN University Chemists obtained coenzyme from Parsley and Dill seeds
Coenzymes of the Q group in mammals and plants are responsible for maintaining the energy metabolism of cells. They are powerful antioxidants and regulate the permeability ofmitochondrial membranes. Coenzyme Q0 is known to reduce and even suppress metastasis in breast, skin and ovarian cancers.
“We proposed a simple way to obtain the necessary element for the synthesis of Q0 precursors based on allylpolymethoxybenzenes. It is easy to isolate them in large quantities from parsley and dill extract,” says RUDN scientist Viktor Khrustalev.
The main stage on the way of obtaining a coenzyme is hydrogenation to allylpolymethoxybenzenes fragments. This process takes place in a special apparatus with a fluoroplastic insert using aporous palladium catalyst. After use, the reaction mixture is separated from the catalyst without additional filters.
The minimum reaction time is 4 to 8 hours. However, with an increased hydrogen pressure,the reaction takes 2-4 hours. Even with accelerated production, no methylbenzene by-products remain after hydrogenation, which simplifies further purification. The catalyst canthen be used up to 40 times.
"With the help of X-ray diffraction analysis, we have confirmed the spatial structure of there sulting compound. This allows further study of its antitumor and antioxidant properties,"explained Viktor Khrustalev, Doctor of Chemistry, Head of the Department of Inorganic Chemistry of the Peoples’ Friendship University of Russia.
The project to develop a cellular model of the placenta became the winner in the Scientific Materials category of the Young Scientists 3.0 competition, organized with the support of the Presidential Grants Foundation and T-Bank.
Ten scientific journals published by RUDN University have been included in the highest level of the state list of scientific publications, the White List.
Forests are not only the lungs of the planet, but also home to millions of species. However, it has remained unclear how underground interactions between trees and fungi affect forest species richness in different climatic conditions. Previous studies have yielded conflicting results: in some regions, the dominance of certain fungi reduced tree diversity, while in others it increased it.
The project to develop a cellular model of the placenta became the winner in the Scientific Materials category of the Young Scientists 3.0 competition, organized with the support of the Presidential Grants Foundation and T-Bank.
Ten scientific journals published by RUDN University have been included in the highest level of the state list of scientific publications, the White List.
Forests are not only the lungs of the planet, but also home to millions of species. However, it has remained unclear how underground interactions between trees and fungi affect forest species richness in different climatic conditions. Previous studies have yielded conflicting results: in some regions, the dominance of certain fungi reduced tree diversity, while in others it increased it.