4
Oncogenesis and mast cells - RUDN scientist Dmitry Atyakshin spoke at an international symposium in Germany

Oncogenesis and mast cells - RUDN scientist Dmitry Atyakshin spoke at an international symposium in Germany

Dmitry Atyakshin, MD, Advisor to the Rector's Office for Biomedical Projects, made a presentation at the International Symposium on Topical Issues of Personalized Oncology, which was held on October 29-30 at the Institute of Hematopathology in Hamburg.

Dmitry Atyakshin made a presentation on "Mast cells in the formation of the immune landscape and regulation of the extracellular matrix of a specific tissue microenvironment (fundamental, diagnostic and pharmacological aspects)". The scientist studied mast cells — cells with a unique regulatory potential of the tumor microenvironment.

Mast cells are key elements in the formation of the tumor microenvironment. They take part in the transformation of the immune landscape, regulation of the state of the integrative buffer metabolic environment, remodeling of the extracellular matrix and the implementation of other pathogenetically significant molecular mechanisms of oncogenesis.

Mast cells can induce tumor progression or initiate its regression, therefore their organ-specific molecular phenotype affecting receptor, secretory and degranulation parameters can not only be used for diagnostic purposes, but also represent promising targets of targeted therapy.

Now mast cells are considered as one of the main cellular representatives of the tumor microenvironment. Many researchers associate the key regulatory effects of mast cells on immunogenesis and tumor stroma with the resulting outcome of the disease and the patient's fate.

At the same time, most of the results obtained are very contradictory and do not allow us to formulate a unified interpretation of the importance of mast cells in angiogenesis, connective tissue remodeling, cell proliferation, changes in the nature of intercellular signaling, further progression and metastasis of the tumor or its regression.

In his research, Dmitry Atyakshin for the first time used the methodological and bionanotechnological capabilities of chromogenic and fluorescent multiplex immunohistochemistry to study a number of selective mechanisms of mast cell involvement in oncogenesis mediated by preformed secretome components. The scientific project is devoted to the analysis of pro- and anti-tumorogenic effects of tumor-associated mast cells.

The scientist investigated the mechanisms of participation of mast cells in the formation of the immune landscape of the tumor and the regulation of the extracellular matrix of a specific tissue microenvironment in melanoma of various localization. The research focuses on the molecular parameters of tumor-associated mast cells in terms of quantitative and qualitative population characteristics, biogenesis and post-translational modification of specific proteases - tryptase, chemase and carboxypeptidase A3.

Dmitry Atyakshin stressed that mast cells as an object of translational studies of oncogenesis are not only promising diagnostic solutions, but also effective targets for cancer immunotherapy. Receptor, secretome and degranulation phenotypes of mast cells are closely related to the molecular portrait of the tumor and can be projected to predict the outcome of the disease or evaluate the effectiveness of therapy.

The interaction of mast cells with immune, stromal and tumor cells determines the unique properties of the tumor microenvironment. Further studies of the molecular phenotype of mast cells open up new pages of effective targets for targeted modulation of oncogenesis to regulate the mechanisms of progression and invasive properties of the tumor.

"Fundamental studies of the tumor microenvironment are extremely in demand, since the degree of progression of oncogenesis and pathomorphosis of the tumor depends on its condition. The scientific problems that are solved by multiplex immunohistochemistry methods in the study of mast cells are important elements for the progress of personalized medicine, including the discovery of new hypotheses of oncogenesis, original diagnostic markers, and, ultimately, effective therapy strategies," Markus Timann, Director of the Institute of Hematopathology Hamburg (Germany).

According to the results of the study, the RUDN scientist will publish research in highly rated journals of the first quartile:

Carboxypeptidase A3 is a key component of the protease phenotype of mast cells.

Tryptase, chymase and carboxypeptidase A3 as informative markers of the secretomic landscape of an organ-specific mast cell population.

Cytological and histotopographic features of specific proteases of tumor-associated mast cells in skin melanoma.

About the event

The International Symposium "Actual problems of pathology in personalized oncology" was held in order to exchange experience in introducing the results of fundamental research into the practical course of medicine - diagnostics and targeted therapy of oncological diseases. The issues of digital medicine, hematological aspects of pediatrics, possibilities of modern diagnostics of oncological diseases and hematopathology, evaluation of treatment results, new strategies of targeted therapy, etc. were considered.


More than 150 well-known specialists from leading medical and scientific organizations in Germany and other countries of the world presented the results of their own research on molecular pathology and personalized oncology - priority areas of activity of the scientific and educational biomedical cluster "Translational Medicine" of the RUDN.


More

Research and Innovative Activity View all
30 Dec 2020
In 2017, RUDN University scientists constructed a new explicit second-order precision difference scheme using modern computer algebra methods for 2-dimensional Navier-Stokes equations (NSE) [1]. This year, our mathematicians used a new scheme [2] to construct a numerical solution to the Cauchy problem with initial data (for t=0) as satisfying the continuity equation. Scientists managed to achieve previously unattainable accuracy of the continuity equation.
572
30 Jan 2018
The conference on international arbitration, where law students from European universities simulate court proceedings and alternately defend the interests of the respondent and the orator.
880
Similar newsletter View all
15 Jul
RUDN and Uralchem Group: New Prospects for Cooperation

On June 16, at the St. Petersburg International Economic Forum-2022 (SPIEF-2022), RUDN and JSC “United Chemical Company URALCHEM (JSC URALCHEM) signed a cooperation agreement. The key goal is the development of higher and additional professional education in the field of foreign trade activities of enterprises of the agro—industrial complex.

315
15 Jul
What was, what is and what will be with the global economy? How one can find place in a changing world?

More than 60 participants from 20 countries took part in the 24th International Research and Practice Conference "Current Problems of the Global Economy", which was held at the RUDN on April 22.

94
31 Mar
Congratulations to Daria Ostrikova on the scholarship of the President of the Russian Federation!

Associate Professor of the Department of Applied Probability and Informatics, scientist Daria Ostrikova has received Russian Presidential Scholarship 2022-2024 for young scientists and post-graduate students. Daria received the scholarship for the implementation of the scientific project "Analytical modeling and techniques of energy efficiency enhancement in 6G terahertz networks" in the direction of modernization "Strategic information technologies, including the issues of creating supercomputers and software development". More about the contest Results of the scholarship competition in 2022 Statistics on the scholarship competition in 2022: 2931 applications were submitted, of which 445 are winners (15 %).

142
Similar newsletter View all