A Chemist from RUDN University Developed a New Method for Combating Antibiotic Resistance in Microbes
Bacteria that are protected by a biofilm are more resistant to antibiotics and other adverse environmental factors, and this resistance usually builds up faster than the modern industry is able to produce new drugs. Such bacteria include salmonella that is a major issue both for medicine and the food industry. Scientists constantly search for new approaches that would help reduce resistance levels in bacteria.
“Our strategy has already proven to be successful against biofilms formation on titanium implants, and we are currently working on expanding its applicability to the industrial and food production fields. Since the mechanism of action was partially elucidated, we have foreseen the potential of our technology to revolutionise the way to fight biofilm associated infections. Our future research will greatly benefit from these findings as resistance development usually poses a major threat to the success of antimicrobials,” said Prof. Erik V. Van der Eycken, the Head of the Joint Institute for Chemical Research at RUDN University.
The strategy is based on inhibiting the formation of bacterial films. In the course of the study, the team mixed two strains of salmonella: one of them was able to form biofilms, and the other wasn’t. Then, the speed of their growth was compared. Similarly, the speed of growth was measured for the same mixture of two strains in the presence of 5-aryl-2-aminomidazole, an inhibitor that slows down film formation. It turned out that the strains that were unable to form biofilms propagated more intensively and forced other strains out.
When the production of biofilm matrix is inhibited, it becomes more difficult for cells to attach to surfaces and their susceptibility to antimicrobial drugs increases. For example, salmonella strains form biofilms both inside and outside of a host making them hard to get rid of by means of mechanical treatment, disinfectants, antibiotics, or the host’s own immune system. The approach suggested by the team could make the fight against pathogenic microorganisms more successful while at the same time preventing the development of resistance.
The new method would increase the efficiency of antibacterial therapy and help combat the most widely spread biofilm infections in medicine, food industry, pharma, and agriculture.
The article was published in the Nature Communications journal.
RUDN University chemists derived molecules that can assemble into complex structures using chlorine and bromine halogen atoms. They bind to each other as “velcro” — chlorine “sticks” to bromine, and vice versa. As a result supramolecules are assembled from individual molecules. The obtained substances will help to create supramolecules with catalytic, luminescent, conducting properties.
RUDN University chemist proposed a new method to create catalysts on a porous silicon matrix with metal nanoparticles. Efficient catalysts for organic reactions are obtained, for example, for the synthesis of vanillin, which is in demand in the food and perfume industry.
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