Development and optimization of techniques for s-, p-, d-elements identification in biomaterials at chemo-toxicological and forensic medical studies

The research is devoted to the development of General methodological approaches for toxic metals and amphoteric elements identification in chemical, Toxicological, forensic and forensic studies.

In vivo screening studies of new photosensitizer for malignant tumors photodynamic therapy

This study focuses on cytotoxic and photodynamic properties of new compounds synthesized by Research Institute of organic semi-products and dyes of polymers State scientific center, examining the potential photosensitizers for PDT of malignant tumors.

Biopharmaceutical study of gemcitabine: antineoplastic drugs belonging to the group of antimetabolites

The study is focused on the development of a system for therapeutic drug monitoring for gemcitabine in patients with pancreatic cancer and Hodgkin's lymphoma based on methods of quantitative determination in drug and blood plasma, HPLC method and kinetics control of general clinical and biochemical parameters.

Spectroscopy in the near infrared region as a method of medicines quality control

The study is focused on the research of the possibility of IR spectrometry in the near range for rapid analysis of medicinal substances and complete dosage forms.

Influence of adverse environmental factors on the occurrence of systemic hypoplasia of the enamel of permanent teeth in children

The research is focused on the improvement of diagnosis, prevention and treatment of dental enamel hypomineralization in children on the basis of examination of influence of adverse environmental factors ю

New approaches to the quality control of medicines based on spectrometry in the near infrared region

The study is devoted to the development of new methods of pharmaceutical substance (PS) analysis based on the method of spectroscopy in the near infrared region. On the first place the variability of NIR spectra in the analysis of drugs in massive production was assessed. The correlation between spectral characteristics and their quality indicators existing in the normative documentation on pharmaceutical substance is determined.

Development and optimization of methods for determination of opiate alkaloids and their derivatives in narcotic drugs and biological materials

The research is devoted to one of the main tasks of criminology and forensic chemistry, which is identification and determination of drug content in biological materials and physical evidence. High-performance liquid chromatography (HPLC) was applied to solve this problem. The application of reliable results of the analysis will increase the objectivity of the examination in administrative and criminal cases.

Interactions between pharmaceutical substance and excipients in aqueous solutions with different Deuterium/Hydrogen composition

The research is devoted to the study of interactions of pharmaceutical substances and excipients in the composition of finished drugs, as well as the influence of isotopic composition of water on biological activity and optical properties of BAS.

Development and standardization of the drug based on amino acids and the rationale for the economic efficiency of its production

The work devoted to the development of the composition, the technology of preparation of the amino-acid drug, its standardization, the determination of the mechanisms of biological activity and the determination of the economic costs of its production.

The study of trace element composition and biological activity of a number of mineral waters

The work devoted to revealing the connection between the content of trace elements of metals and the biological activity of mineral waters as combined preparations of inorganic nature.