Scientific seminar of post-doc S. Cherukupalli «Design and synthesis of novel pyrrole analogues from imidazolines as anticancer agents»
Heterocycles hold a key point in organic and medicinal chemistry as they act as a bridge between life sciences and biochemical investigations. A significant amount of contemporary investigation is being currently pursued on these compounds worldwide. Aza-heterocycles are essential scaffolds for generating wide range of chemical libraries/drug-like candidates for their applications to obtain desired theapeutic/pharmacological activity. Among all the aza-heterocycles, pyrrole is one such essential drug-like nucleus bearing enormous biologically applicability. This moiety is known to possess diverse biological applications as antimetabolites in purine bio-chemical interactions, antischistosomal, antitrypanosomal and sedative, anxiolytic, benzodiazepine receptor ligands, HMG-CoA reductase inhibitors, KDR kinase inhibitors, COX-1, COX-2 selective inhibitors, HCV inhibitors, PET tumor imaging agents, serotonin 5-HT6 receptor antagonists, kinase inhibitors, HIV reverse transcriptase inhibitors, CCR1 antagonists, antimalarial and antifungal activities.
Based on the above-mentioned facts and in continuation of our research work on synthesis of novel heterocyclic compounds (pyrrole), we envisage to develop new synthetic methodology for the synthesis of novel pyrrole analogues from imidazolines through 3,3-sigmatropic rearrangement. Further the synthesized compounds are evaluated for in vitro and in vivo anticancer studies.