Molecular design and synthesis of innovative compounds for medicine
Molecular design and synthesis of innovative compounds for medicine

Type

Center

Department

Research Institute of Chemistry (RIC)

Head:

Andrey Malkov

PhD, Professor of Chemistry Professor of Organic Chemistry, Loughborough University, England

Contacts:

#W

a.malkov@lboro.ac.uk

Structural unit: Research Institute of Chemistry (RIC).

The Center’s activity is aimed at:

  • research activities in synthesis of bioactive azaheterocycles based on domino-reactions of oxacarbenium ions;
  • development of innovative methods and technologies for the preparation and study of vinyl iminium ions and donor-acceptor cyclopropanes

Goals of the Center:

the research and study of chemical compounds and methods for their rational and economical synthesis;
search and analysis of previously unknown preproducts and bioactive compounds with potential application in the pharmaceutical industry.

The Center’s Objectives – solution of chemical problems of heterocyclic compounds, nitroalkanes, ionic liquids, surfactants as well as searching for new, previously unknown and unexplored PD-sensors  

Main scientific directions All directions
  • study of cascade reactions in synthesis of heterocyclic (nitrogen, oxygen) compounds;
  • nitroalkane reactions in polyphosphoric acid;
  • potentiometric PD-sensors based on various organic membranes;
  • ionic liquids based on tetrasubstituted arenes with quaternary ammonium fragments;
  • nickel electroplating from aqueous solutions containing aminopolycarboxylic and carboxylic acids;
Achievements

New approaches to the synthesis of bioactive aza-heterocycles based on domino-reactions of oxacarbenium ions, iminium ion vinyls and donor-acceptor cyclopropanes.