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The chemist from RUDN University, together with the colleagues, first created molecules’ catchers for energy source molecules of cells
The chemist from RUDN University, together with the colleagues, first created molecules’ catchers for energy source molecules of cells
For the first time, a team of Russian scientists together with RUDN University synthesized calixarenes capable of “trapping” adenosine triphosphoric acid (ATA) molecules and enclosing them inside their cavity. ATA molecules are a universal source of energy for most biochemical processes. They also act as an intercellular mediator.

The authors created a kind of molecular sensor that can not only recognize the ATA molecule among others, but also “capture” it. This was achieved thanks to the attachment to the upper part of the "bowl" of molecular receptors - groups of atoms that selectively bind only to compounds of a certain type. The atomic groups containing nitrogen introduced by scientists have shown high efficiency in the binding of ATA in solution.
Scientists synthesized several types of calixarenes. The first type included compounds with two or four attached receptors in the upper part of the molecule, the second in the lower part of the molecule. The remaining several types included combinations of the first two. After a detailed analysis of the chemical properties of each type of compound, the scientists revealed differences in their behavior and properties.
So, for example, when two specific groups are inserted in the lower part of the molecule, it begins to more efficiently bind adenosine diphosphoric acid (ADA) - a compound formed during the partial decomposition of ATA.

“Over the past two decades, many research groups have paid great attention to the synthesis of host molecules with high affinity for biologically important substances. Among these methods, the recognition and transfer of nucleotides — adenosine diphosphoric and adenosine triphosphoric acids — is of particular importance due to their great biological significance. Adenine-containing nucleotides are important as a universal source of energy and as intracellular mediators in many biological processes. For the first time, we created molecules based on calixarenes that can recognize ATA and ADA in a solution and bind to them at low concentrations ”says Viktor Khrustalyov, one of the authors of the work, doctor of chemical sciences, head of the inorganic chemistry department of the RUDN University.

Main Publications View all
15 Nov 2017
RUDN University scientists publish results of their scientific researches in highly-recognized in whole world and indexed in international databases journals (Web of Science, Scopus ect.). That, of course, corresponds to the high status of the University and its international recognition. Publications of June-September 2017 ( In Journals of categories Q1-Q3)
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Scientific Conferences View all
03 Nov 2017
RUDN University organized the first 5G Summit R&D Russia on June 19 - 20, 2017
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02 Apr
The Financial Support of RUDN Scientific Journals: Results Are Announced

The results of the contest launched to support the development of scientific journals of RUDN University are summed up. The purpose of the contest is to contribute to the improvement of the academic reputation of RUDN University both as a research center and a publisher of authoritative scientific journals.

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02 Apr
RUDN Tree Talkers Will Monitor the State of Trees in Moscow

In 2020, the Moscow City Government will begin to monitor urban trees using devices created by RUDN scientists. This was announced by the head of Moscow Department of Nature Management and Environmental Protection Anton Kulbachevsky during the 20th anniversary meeting of the Panel of the Department. The event was held on March 2, 2020. Elvira Dovletyarova, head of the Department of Landscape Design and Sustainable Ecosystems of the Agrarian and Technological Institute of RUDN University took the floor as a visiting expert.

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02 Apr
RUDN University Chemist Invented a "Line Production" Method of Synthesis of 28 Biologically Active Molecules

A chemist at RUDN University has invented a new method for the synthesis of a large group of complex poly-heterocyclic organic compounds, which draw interest as possible future medications. The researcher turned to a two-step reaction, in which he used affordable and cheap organic reagents and catalysts based on gold, which allowed him to synthesize as many as 28 new molecules. This approach will significantly expand the libraries of biologically active substances. The work was published in Organic & Biomolecular Chemistry.

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