The history of the "Perftoran" must be continued
The history of the "Perftoran" must be continued
At the end of the last century, Soviet scientists proposed the drug “Perftoran” as a blood substitute, which today could safely be called innovative. Created on the basis of perfluorocarbon compounds, it could compensate for the lack of oxygen in the patient’s body due to the absorption mechanism of its transfer. However, the composition, unofficially named for the color “blue blood”, revealed certain shortcomings, which the authors were not able to eliminate at the time. We could not do it abroad.

Employees of the center for collective use (Scientific and educational center) of the Russian Academy of Sciences took up this difficult task. The reason for this was the developing COVID-19 pandemic in the world.

It is known that oxygen deficiency affects the severity of ischemic brain and heart damage, shock and collapse states, infectious and non-infectious diseases, the formation of multiple organ failure and stressful situations.

The research team led by the Director of the center for biotechnology and synthesis of Common Use Center (Research and Educational Center) of RUDN University Arkady Khromov formed a new algorithm for obtaining perfluorocarbon blood substitutes with nanoscale emulsion particles, which will ensure its low viscosity and oxygen delivery to the final link of the systemic blood flow — the capillary. The developers also know how to make the infusion drug stable during its long-term storage without freezing.

To implement the project, funding is required. To date, an application for a grant from the Russian Foundation for basic research (RFBR) on the topic “Fundamental research on the development of drugs based on perfluorocarbon compounds for the delivery of oxygen to the body tissues of a patient infected with coronavirus” has been issued.

We wish our colleagues good luck in achieving this goal.

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Michele Pagano is a graduate of the University of Pisa, a leading scientist, the author of more than 200 publications in international journals, and a participant in many international research projects
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