Development of new methods for the synthesis of natural compounds and their analogues based on domino reactions and highly selective reagents
Objective: a study of the mechanisms of new reactions, thermodynamic/kinetic control of reversible processes. A series of compounds of each type will be subjected to tests of biological activity, and the results obtained, after analyzing them, will outline ways to further modify the basic structures and proceed to the next stage — an assessment of toxicity and in vivo bioactivity. As a result of the research, effective approaches will be developed to obtain potentially practically useful substances, mainly with the help of new, original transformations. This will significantly expand the knowledge of the chemistry of indole, furan and chroman, and make a wide range of new heterocycles available for biological screening. The proposed approaches to target compounds and other results correspond to the world level, and in a number of positions, they exceed it.
New approaches to the synthesis of physiologically active azaheterocycles based on the domino reactions of oxacarbenium ions, vinylogues of iminium ions and donor-acceptor cyclopropanes
As part of the research, new effective approaches to biologically active heterocyclic compounds are being developed based on simple transformations of readily available starting compounds; subclasses of molecules, bioisosteric, known bioactive natural compounds and synthetic drugs, are synthesized based on polyfunctional compounds used as multi-center reagents in organic synthesis. In addition, new multicomponent reactions are being developed based on the interaction of isonitriles and azides with 3-alkyl-adenine-indinine salts and cationic intermediates generated from ketals and polyfunctional acetals. As a result, new multicomponent reactions will be developed based on the interaction of isonitriles and azides with 3-alkyl-adenine- indinine salts and cationic intermediates generated from ketals and polyfunctional acetals; effective approaches to the synthesis of biologically active derivatives of tetrazole and indole — analogues of natural nucleosides and known antitumor preparations — have been created. On the basis of the developed approaches, it is planned to carry out a complete synthesis of a number of natural compounds (krispip A, trollip, mescatol).