In process of scientific search not lose ability to doubt always.
Graduated from the Peoples’ Friendship University of Russian, Medical Faculty, specialty “General Medicine”.
Candidate of Medicine, Candidate thesis on “Pathophysiological mechanisms of the influence of the calcium antagonist verapamil on morphological and functional state of myocardium in the stage of development of compensatory hypertrophy” was defended.
Assistant, from 2009 – associate professor, from 2013 - professor of the Department of General Pathology and Pathological Physiology, the Institute of Medicine RUDN.
Head of the Scientific and Educational Laboratory of functional research methods, chronobiology and chronocardiology of RUDN.
Doctor of Medicine, Doctoral thesis on “Apoptosis of cardiomyocytes as a model reaction of the altered heart”.
Director of the direction of training of highly qualified personnel in postgraduate school 30.06.01 “Fundamental Medicine”.
Member of the editorial Board of the journal “Bulletin of RUDN. Series Medicine”.
The academic title of Associate Professor on specialty “Pathological Physiology” was awarded.
Head of the Department of General Pathology and Pathological Physiology named after Frolov V. A. the Institute of Medicine RUDN University.
Deputy Chairman of the dissertation Council D 212.203.06 at RUDN (14.03.03 “Pathological Physiology”, 14.03.02 “Pathological Anatomy”).
Member of the editorial Board of the journal “Bulletin of experimental biology and medicine”.
Full member of the International Higher Education Academy of Sciences (IHEAS) on the “Science of Man”.
Gratitude of the Rector of RUDN University for the significant contribution to the implementation of RUDN National project “Education”.
Diploma of the scientific Council of RUDN University for conscientious labour, considerable contribution in development of medical education in RUDN University and in connection with the 55th anniversary of the Medical Faculty.
Conducts lectures and practical classes in Russian and English for 3rd year students of the Institute of Medicine RUDN University:
- “Pathophysiology, clinical pathophysiology” (for specialty - “General Medicine”),
- “Pathophysiology - pathophysiology of head and neck” (for specialty - “Dental Medicine”),
- “Pathology” (for the specialty “Pharmaceutical Science”)
- Provides training of highly qualified personnel (in postgraduate school) in medical Sciences in the specialty 14.03.03 “Pathological Physiology”.
The author of the following course-books and study guides:
- Frolov V. A., Blagonravov M. L., Demurov E. A., Bilibin D. P., Velichko E. V. Particular pathophysiology: study guide. - Moscow: Practical medicine, 2017. - 264 p. (Stamp of FIED of the Ministry of Education and Science of the Russian Federation)
The study guide includes all the topics that are discussed in the section “General Pathophysiology”. The material covers all the key issues that form the basis of this area of medical knowledge. Each topic includes definitions of basic concepts, classifications, descriptions of etiology, mechanisms of development and outcomes of the studied pathological processes and a number of specific diseases. The study guide was written in accordance with the programs of disciplines developed to meet the requirements of the FSES. For University students studying in “General Medicine”, “Dental Medicine”, “Pharmaceutical Science”, residents of all profiles and postgraduate students studying in the directions of “Fundamental Medicine”, “Clinical Medicine”.
- Frolov V. A., Blagonravov M. L., Demurov E. A., Bilibin D. P., Velichko E. V. General pathophysiology: study guide. - M.: Practical medicine, 2016. - 224 p.
The study guide includes all the topics that are discussed in the section “Particular Pathophysiology”. The material covers all the key issues that form the basis of this area of medical knowledge. Each topic includes definitions of basic concepts, classifications, descriptions of etiology, mechanisms of development and outcomes of the studied pathological processes and a number of specific diseases. The study guide was written in accordance with the programs of disciplines developed to meet the requirements of the FSES. For University students studying in “General Medicine”, “Dental Medicine” and “Pharmaceutical Science”.
- Blagonravov M. L., Frolov V. A. Non-coronary diseases of the myocardium: study guide. - M.: Practical medicine, 2016. - 96 p.
The study guide presents material on a number of issues included in the section “Particular Pathophysiology” on myocardial diseases, etiologically and pathogenetically unrelated to the pathology of the coronary arteries. In addition to the existing course-books on pathological physiology, this study guide is intended for more profound study of relevant topics. In addition to describing the key concepts, classifications, etiology and pathogenesis of noncoronarogenic myocardial diseases, each chapter provides the basics. The study guide was written in accordance with the programs of disciplines developed to meet the requirements of the FSES. For University students studying in “General Medicine”, “Dental Medicine” and “Pharmaceutical Science”, residents of all profiles and postgraduate students studying in the directions of “Fundamental Medicine”, “Clinical medicine”.
- the concept of programmed cell death as a model reaction of altered heart was developed. It was defined that cardiomyocyte apoptosis is a nonspecific cardiac response to injury that is mediated by various initial mechanisms and can be directed to the elimination of damaged and functionally defective cellular elements. Currently, this concept was developed in relation to the molecular mechanisms that provide protection of myocardial cells in the developing pathology of the heart.
- the scientific group under the leadership of M. L. Blagonravov studies pathogenetic mechanisms of violations of the rhythmic organization of the functions of the cardiovascular system, including using a unique technology of 24-hour telemetry monitoring of physiological functions. In particular, the influence of different types of light regime on the state of biological rhythms of the cardiovascular system in hypertension is studied. It has been shown that with a pronounced deficit of visible light in the chrono-structure of the heart rate there are changes that can limit the adaptive reserves of the body. On the other hand, excessive exposure to visible light has a more pronounced and less favorable effect on the body in hypertension.
- Pathophysiology of the cardiovascular system,
- Programmed cell death,
Information about the defended postgraduate students
Year of protection: 2015
Research topic: Functional characteristic of chronostructure of the cardio-vascular system in the dynamics of genetic hypertension
Annotation to the dissertation: In the present work some indices characterizing functional state of the cardio-vascular system under long-term hypertension were studied. As a target of research we used spontaneously hypertensive rats (SHR) and normotensive Wistar rats (control) in which we implanted (surgically) radio-transmitters monitoring BP, ECG and motion activity for several months continuously. The obtained data were processed with computer programs: Dataquest A.R.T.4.2 Gold (USA) и ChronosFit (Germany). It was found that maximal daily systolic BP significantly increased at the stable stage of hypertension; inhibition of the chronotropic function of the myocardium at the late terms of the experiment was also typical. It was shown that rhythmic characteristics of the investigated indices were gradually suppressed as hypertension was developing which was also accompanied by disorganization of their circadian profiles.
Year of protection: 2016
Research topic: Pathogenic features of cell death in myocardial alterations of different genesis
Annotation to the dissertation: In the present work the features of initiation of cardiomyocyte regulated cell death at the early stages of cardiac alteration of different etiology were studied. The experiments were performed on male rabbits in which we modeled acute ischemia of the left ventricle, hemodynamic overload of the left ventricle and a diffuse toxic damage of the myocardium. Мechanisms of cardiomyocyte autophagy and apoptosis were evaluated by means of morphological and immunohistochemical investigation of the myocardium. Cardiomyocyte autophagy was studied by estimation of protein BECN1 expression, apoptotic process in cardiomyocytes – by estimation of proapoptotic protein BAX and antiapoptotic protein BCL-2. It was found that mechanisms mediating realization of some types of cardiomyocyte regulated death may have different properties depending on the character of myocardial damage. It was shown that under acute myocardial ischemia the activity of BECN1-induced cardiomyocyte autophagy is increased and on the 1-st day there is also activation of mitochondrial pathway of cardiomyocyte apoptotic death. Acute toxic damage and acute overload of the left ventricle are accompanied by inhibition of cardiomyocyte autophagy.