Svetlana Kovaleva

Research and Innovation

RUDN Scientists

Svetlana Kovaleva

Candidate of Chemical Sciences

Associate Professor of the Department of Pharmaceutical Chemistry and Pharmacognosy of Shared Research and Educational Center RUDN University,

It is necessary to doubt in experimental works as long as the facts do not force to relinquish any doubts.

Scientific interests:

organic chemistry chemistry of heterocyclic compounds organic synthesis mass spectrometry NMR spectroscopy

2008

Graduated from Peoples’ Friendship University of Russian, Faculty of Physics, Mathematics and Natural Sciences, Master of Chemistry.

2010

Engineer of the Center for precision instrumental methods of analysis “Prima” of Shared Research and Educational Center RUDN.

2011

Candidate thesis on "Transformation tetrahydrobenzothienopyridines, tetrahydropyridothienopyrimidines and tetrahydrobenzofuropyridines under the action of alkynes” on the speciality 02.00.03 Organic chemistry was defended.

2011

Deputy director of the Center for precision instrumental methods of analysis of Shared Research and Educational Center RUDN.

2015 - present

Deputy director of the Center for Drug Quality Control of Shared Research and Educational Center RUDN University.

2015 - present

Associate professor of the Department of Pharmaceutical Chemistry and Pharmacognosy of Shared Research and Educational Center RUDN.

Science

Co-author of the patent “Method of producing derivatives 3’,4’,5,6-of tetrahydro-1H-spiro[pyridine-4,5’-thieno[2,3-d] pyrimidines]” (a new method of obtaining 3’,4’,5,6-tetrahydro-1H-spiro[pyridine-4,5’-thieno[2,3-d] pyrimidines] which may be of interest in medicine).
Regularities of transformation of tetrahydrobenzothieno[2,3-s] pyridines and tetrahydropyrido [4’,3’:4,5] thieno[2,3-d] pyrimidines with different structures, as well as tetrahydrobenzothieno[2,3-s]- and [3,2-s] pyridines under the action of methylpropiolate, acetylacetylene and ADCE in various solvents were systematically studied for the first time.
Methods for the synthesis of various heterocyclic systems: spiro[benzothiophene-3,4’-pyridines], spiro[pyridin-4,5’-tisno[2,3-d] pyrimidines], spiro[benzofuran-2,4’- and 3,4'-pyridines] and tetrahydroazocines condensed with benzothiophene and 4-oxopyrimidine fragments in search of synthetic approaches for production of new biologically active heterocyclic compounds were developed.

Ovcharov M.V., Barsegyan S.S., Kovaleva S.A., Kulikova L.N., Borisov R.S. New Approaches to the Application of DART Mass Spectrometry Coupled with Planar Chromatography for the Analysis of Mixtures of Organic Compounds. -Journal of Analytical Chemistry. -2017. -72(14), -с. 1446-1450

A desorption cell for TLC/DART mass spectrometry is developed. An analysis of mixtures of pharmaceutical substances has shown that the proposed approach can improve the sensitivity of the method and achieve the reproducibility of the recorded mass spectra and selected ion chromatograms.

Voskressensky L.G., Kovaleva S.A., Borisova T.N., Titov A.A., Listratova A.V., Varlamov A.V., Toze F., Khrustalev V.N. Synthesis of 2-(chloro(methoxy, morpholino)methyl)-hexahydropyrimidothieno[3,2-c]azocines and tetrahydrospiro[pyrido[4,5']thieno[2,3-d]pyrimidines]. -Chemistry of Heterocyclic Compounds. -2015. -Т. 51. -№ 1. -С. 17-25

2-(Chloromethyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3Н)-ones reacted with acetylenedicarboxylate ester, methyl propiolate or acetylacetylene, forming mixtures of 2-(chloromethyl)-5,6,7,10-tetrahydropyrimido[5',4':4,5]thieno[3,2-d]azocin-4(3Н)-ones and 2'-chloromethyl-6'-methylidene-2,3-dihydro-1Н-spiro[pyrido[4,5']thieno[2,3-d]pyrimidin]-4'(3'H)-ones in various ratios. Analogous products were also obtained in the reaction of 2-(methoxymethyl) derivative with methyl propiolate, while using 2-[(morpholin-4-yl)-methyl] derivative in a similar reaction led to the formation of a more complex product mixture.

Voskressensky L.G., Kovaleva S.A., Borisova T.N., Listratova A.V., Varlamov A.V., Eresko A.B., Tolkunov V.S., Tolkunov S.V., De Candia M., Altomare C. Recyclization of benzofuropyridines by the action of activated alkynes in the synthesis of spiro[benzofuropyridines], representatives of a new class of acetylcholinesterase inhibitors. -Chemistry of Heterocyclic Compounds. -2013. -Т. 49. -№ 6. -С. 930-940

A study was carried out on the domino transformations of tetrahydrobenzofuro[2,3-c]pyridines and tetrahydrobenzofuro[3,2-c]pyridines by the action of activated alkynes in methanol and acetonitrile. This reaction is a new method for the synthesis of spiro[benzofuropyridines] showing acetylcholinesterase inhibition activity.

Voskressensky L.G., Borisova T.N., Kovaleva S.A., Listratova A.V., Kulikova L.N., Khrustalev V.N., Ovcharov M.V., Varlamov A.V. Transformations of tetrahydropyrido[4′,3′:4,5]thieno[2,3-d] pyrimidin-4(3H)-ones in the presence of alkynes bearing electron-withdrawing substituents. - Russian Chemical Bulletin. -2012. -Т. 61 (2), -С. 370-379

Tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidines in the presence of activated alkynes were transformed into mixtures of pyrimido[5′,4′:4,5]thieno[3,2-d]azocines and spiro[pyridine-4,5′-thieno[2,3-d]pyrimidines].

Voskressensky L.G., Kovaleva S., Borisova T.N., Varlamov A.V., Eresko A.B., Tolkunov V.S., Tolkunov S.V., Khrustalev V.N. Novel synthetic route toward benzofuran-pyridine-based spirans. -Synthetic Communications. -2012. -Т. 42. -№ 22. -С. 3337-3343.

A novel domino reaction of tetrahydrobenzofuro[3,2-c] or [2,3-c]pyridines with dimethylacetylene dicarboxylate (DMAD) or methyl propiolate (MP) resulted in the formation of spirobenzofuranpyridines in moderate yields. The spirobenzofuran derivatives reported may be considered analogs of the antifungal drug griseofulvin.

Voskressensky L.G., Kovaleva S.A., Borisova T.N., Listratova A.V., Varlamov A.V., Eresko A.B., Tolkunov V.S., Tolkunov S.V. Tandem transformations of tetrahydrobenzothieno[2,3-c]pyridines in the presence of activated alkynes. -Tetrahedron. -2010. -Т. 66. -№ 48. -С. 9421-9430.

The reactivity of some new tetrahydrothienopyridines towards activated alkynes was investigated. A novel cascade cleavage-spiroannulation process, leading to the formation of previously unreported derivatives of 1′H-spiro[1-benzothiophene-3,4′-pyridine] was discovered and studied.

Voskressensky L.G., Listratova A.V., Borisova T.N., Kovaleva S.A., Borisov R.S., Varlamov A.V. The first example of tetrahydrothieno[3,2-d]azocines synthesis. -Tetrahedron. -2008. -Т. 64. -№ 45. -С. 10443-10452.

A novel and efficient one-pot synthesis of thieno[3,2-d]azocines based on tandem transformation of tetrahydropyridine ring was elaborated.