Cascade transformation brought a victory in a competition to RUDN chemists
Cascade transformation brought a victory in a competition to RUDN chemists

The study "Dinitriles’ cascade transformations in basic medium" won the category "Chemistry, new materials and chemical technologies" of a contest of state support of young Russian PhD holders.

The research is aimed to create new domino reactions - effective methods for synthesis of organic compounds that might display useful properties.         

RUDN scientists of the Faculty of Science conducted a series of studies of the properties of cyanomethyl thiazolium salts undergoing domino-reaction with salicylic aldehydes. Biological studies compounds obtained that way demonstrated their high cytotoxic activity. Detailed results offer hope for improving the effectiveness of some medications, including those against cancer.

"We pursue two main objectives in our studies - says the author - Aleksey Festa, PhD (Chemistry), Senior Lecturer at Organic Chemistry Department - Firstly, we want to create interesting and beautiful fundamental chemistry. Secondly, we are focused on the practical relevance which can manifest itself in the form of a biological activity or fluorescence properties of the compounds we obtain.

We hope to strengthen our cooperation with biologists, to make our hit-compounds candidates for medicine."

Creation of new types of domino processes inevitably attracts the attention of researchers from all over the world. Every year more than 500 studies are published in this research field.

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