An ischemic stroke can lead to death, disability, cerebral edema, alteration of consciousness, and other complications that considerably affect the quality of the patients’ lives. The method of selective cerebral hypothermia is used to treat cerebral edema and reduce intracranial pressure. According to RUDN medics, some treatment standards included into this method are incorrect.
In the course of selective cerebral hypothermia the brain cortex is cooled off causing the body’s activity to slow down and relieving the edema. This effect is reached using a special helmet with 0-8℃ liquid circulating inside it. The method also slows down the metabolism, and the patients need to make adjustments to their diets for the period of therapy. Previously, the patients were expected to get 20-25 Kcal per 1 kilogram of body weight. For an average weight person this means about 1,600 Kcal a day - two times less than it is required by healthy people. RUDN medics demonstrated that these values were incorrect. In fact, the amount of calories should be reduced by 15-20%.
The researchers divided 27 ischemic stroke patients from 53 to 80 years old into two groups. The first one was treated using the selective cerebral hypothermia method, and the other one - without it. All other therapy aspects were the same in both groups. The diet of the patients was developed in view of their energy consumption and daily protein loss. The first group showed positive dynamics 24 hours after the beginning of the treatment, and the second one - none at all. After the patients in the first group underwent selective cerebral hypothermia, all their health indicators went back to normal. As a result, the scientists demonstrated that standard dietary recommendations for such patients had little efficiency and recommended reducing the dosage by 15-20%.
“The neuroprotective effect of therapeutic hypothermia has already been acknowledged all over the world. However, we have to continue clinical studies and optimize the therapy. We provided new recommendations regarding calorie value reduction in case of hypothermia. Currently, they are only preliminary, but one may expect our method to reduce the morality and disablement rate in the patients with ischemic stroke,” said Oleg Shevelev, Professor of V.A. Frolov Department of General Pathology and Pathological Physiology at RUDN.
A chemist from RUDN University has created platinum complex compounds that are superior in activity to cisplatin, the drug for the treatment of tumour diseases. The new compounds turned out to be also less toxic to healthy cells.
Biologist from RUDN University Morteza Yousefi has found that lavender extract added to the food reduces stress and improves immunity in carp in fish farms. The discovery may be used in fish farming.
Every year in Russia, about 4 thousand children need help of cancer surgeons. The lives of children depend on the professionalism and knowledge of surgeons. RUDN experts share relevant information and many years of experience for the first time in Russia, presenting systemic knowledge of pediatric thoracoabdominal oncological surgery in an encyclopedia published by a professor at the Faculty of Continuing Medical Education of RUDN University, Doctor of medical sciences Andrey Ryabov. The book is edited by the former chief oncologist of Russia, a brilliant oncologist surgeon, legendary academician Mikhail Davydov.