Common Use Center (Research and Educational Center)
Common Use Center (Research and Educational Center)

Type

Center

Head:

Rimma Abramovich

Doctor of Law, Doctor of Economics

CUC (REC) of RUDN University was established in July 2009 as part of an innovative educational program.

The objective of the center’s activities is to integrate intellectual, material-technical, technological and organizational resources for the implementation of academic and research activities in the sphere of research, standardization, quality control of substances, materials and finished products.

Scope of usage of the Center instruments:

  • development and improvement of the technology of the production of original and generic ready-to-use medicines (supplements, cosmetic products) in solid (tablets, capsules), soft (suppositories, gels, ointments, creams, transdermal therapeutic systems, rapidly dissolving films) and liquid (eye drops, injection solutions, suspensions) dosage forms;
  • identification of counterfeit medicines, dietary supplements and food products;
  • analysis of biological materials;
  • determination of the composition of medicines, dietary supplements and food products;
  • determination of medicinal products and their metabolites in biological fluids (blood, urine, amniotic fluid) and extracts of internal organs (brain, liver) within preclinical and clinical research of medicines;
  • determination of the qualitative and quantitative composition of medicines;
  • determination of the qualitative and quantitative composition of complex multi-component objects.

In CUC (REC) of RUDN University there are 300 items of the main and auxiliary equipment used for conducting fundamental and applied research and addressing a wide range of scientific and scientific-practical problems. All the equipment of CUC (REC) of RUDN University is properly checked every year and qualified in accordance with GMP and GLP rules.

Main scientific directions All directions
  • development of original and generic compositions and pharmaceutics, dietary supplements and cosmetic products;
  • development of experimental-industrial batches of medicines for clinical and preclinical research;
  • contract production of non-sterile medicines and preparations from plant raw materials;
  • preclinical research of medicines;
  • implementation of the chemical-analytical part of clinical research;
Achievements All achievements

Creation and study of ready-to-use dosage forms from the stage of synthesis of a medicinal substance to the production of experimental-industrial batches of medicines, including innovative ones;

Expert assessment of the quality of medicinal raw materials and medicinal products made of medicinal plant raw materials;

Provision of services of conducting the quality assessment of hypoglycemic agents (injection forms);

Used equipment See all
Flow-Through Cell Dissolution Apparatus USP-4
Conducting a test for the dissolution of such dosage forms as suppositories, powders, medicinal substances, suppositories, suspensions, liposomes, microspheres, semi-solid substances, implants and medical devices, for example, drug-eluting stents in accordance with current requirements of regulatory documents.
High-performance liquid chromatograph Agilent 1200
Development of methods of qualitative (identification, confirmation of authenticity) and quantitative analysis (content of an analyte, presence and content of impurities) in the field of environmental control, food safety assurance, including dietary supplements, in pharmaceutical control at all stages of "life" of a medicinal product from molecule to ready-to-use dosage form.
High-performance liquid chromatograph Agilent 1290
Development of methods of qualitative (identification, confirmation of authenticity) and quantitative analysis (content of an analyte, presence and content of impurities) in the field of environmental control, food safety assurance, including dietary supplements, in pharmaceutical control at all stages of "life" of a medicinal product from molecule to ready-to-use dosage form.
High-performance liquid chromatographs (3 items) LC-20 Prominence
Development of methods of qualitative (identification, confirmation of authenticity) and quantitative analysis (content of an analyte, presence and content of impurities) in the areas of environmental control, food safety assurance, including dietary supplements, in pharmaceutical control at all stages of "life" of a medicinal product from molecule to ready-to-use dosage form.
Scanning electron microscope “JSM-6490LV”
Used for quality control and certification of products manufactured with the use of nanotechnologies. Equipped with a low vacuum system, which allows observing water-saturated or non-conductive samples without sputtering. For the study of objects with a diameter of up to 8 inches.
Chromatography-mass spectrometer JMS-T100LP-DART (JEOL, Japan) with a liquid chromatograph Agilent 1100
Analytical support of preclinical and clinical research, including research of pharmacokinetics and bioequivalence. Highly sensitive determination of medicinal substances and their metabolites in biological media of humans and animals (blood, urine, amniotic fluid, etc.). Ultrafast analysis of any solid, liquid and gaseous objects without prior sample preparation and chromatography using a unique ion source DART-MS.
Nikon Eclipse 90i confocal microscope
Quantitative analysis of the structural-functional state of microobjects based on the information on their molecular composition, visualization of processes of interaction of biological macromolecules, measurement of the rate of change in the concentrations of substances in fast-flowing processes in local areas of microobjects, etc.
Chromatography-mass spectrometer JMS-GCMate II (JEOL, Japan) with a gas chromatograph Agilent 6890N
A magnetic-sector mass spectrometer for research purposes that provides reliable identification and quantitative analysis of substances at the level of picograms in combination with chromatographic separation.
Hybrid quadrupole time-of-flight chromatography-mass spectrometer micrOTOF-Q
Used for the qualitative and quantitative analysis of medicines and metabolites in biological fluids. Confirmation of the molecular formula, generation of new formulas, multi-purpose screening, biomarker research and analysis of intact proteins, etc.
Mass spectrometric system DELTA V ADVANTAGE for the analysis of stable isotopes
Designed to determine the ratios of concentrations of stable isotopes. Scope of application: geology, petrochemistry, biology, forensics, food industry, analytical control of environmental objects, etc.
Preparative HPLC LC-20 Prominence 8040
A chromatographic separation system designed to isolate, purify and produce the required amounts of analytes (from microgram to gram quantities of reaction mixtures, ready-to-use dosage forms, medicinal plant and animal raw materials).
600 MHz NMR spectrometer JNM-ECA 600
The spectrometer is used in chemistry, medicine, ecology, energy and other industries for the most qualitative and accurate analysis of the composition of liquid media to determine such important indicators as the structural formula, the electronic and spatial structure of a substance, the degree of its purification and isotopic composition, fragmentary, structural-group and component composition, the hierarchy of technological transformations.
Analytical complex of the liquid chromatography-mass spectrometer with triple quadrupole LCMS-8040
The qualitative and quantitative analysis of complex multi-component water-organic systems by using ultra-high-performance liquid chromatography in combination with mass-spectrometric detection of analytes. The study of the spectrum of lipid mediators (158 products of oxidation of arachidonic, eicosapentaenoic, docosahexaenoic and other acids).
Automatic cartoning machine IMA, A8
Monoblock blister and cardboard machine for pharmaceutical solid oral dosage forms in the form of tablets, capsules and dragees. The blister line is capable of processing a wide variety of packaging materials.
Laboratory rotary tablet press “XSpress”
Modern high-tech device for creating and testing of the formulation technology in experimental-industrial production, allows to work out the formulation technology on small batches with minimal cost and enables further scaling in industrial production.
Laboratory coating machine (mini-coater Glatt "GMPCI")
Laboratory machine for general purpose, intended for research and development in the process of tablet coating.
Extrusion and spheronization unit ZE 9
A machine for continuous processing of polymeric raw materials (granules, hogged chips, agglomerate) into a homogeneous melt and shaping it by punching through an extrusion head and a special calibrating device. It allows obtaining dosage forms, which provide a controlled release of the active substance. The unit works in full compliance with GMP, FDA and ATEX standards.
Laboratory machine for the production of transdermal patches and rapidly dissolving oral films "PML-100"
Production of transdermal patches: unwinding, winding, cutting, dosing of active substances and sealing of sachets. Rapid and simple production of small batches of medicines for research and clinical purposes.
Station for filling solid dosage forms with thixotropic liquids
The additional module to the multifunctional innovative machine for filling and closing of hard gelatin capsules, which allows working with thixotropic liquids.
Capsule filling machine "Modu C LS"
Multifunctional innovative machine for filling and closing of hard gelatin capsules, which allows working with various fillings: powders (from the smallest (1-30 mg)), pellets, granules, thick and viscous liquids and mixtures of these products. Capacity: 7,000-24,000 capsules/hour. The machine is designed for testing new active ingredients, production and generation of small and preliminary batches.
Partners

City

Turku, Finland

Subject of cooperation:
Scientific research
Result of cooperation:

Creation of a metabolome technology that allows to analyze the qualitative and quantitative composition of herbs and their parts, predict and study the influence of various factors on the synthesis and accumulation of certain classes of organic compounds

City

Basel, Switzerland

Subject of cooperation:
Scientific research
Result of cooperation:

Increased bioavailability of medicines

City

Kiel, Germany

Subject of cooperation:
Scientific research
Result of cooperation:

Increased bioavailability of medicines