Events and Invitations
Events
2019
24 Dec
Efimov Ilia «Synthesis of new BODIPY compounds based on 1,2,4-oxadiazolyl-1H-pyrroles»
The new BODIPY compounds were synthesized based on 1,2,4-oxadiazolyl-1H-pyrroles. The strategy for this new BODIPY was used as reaction azolylenamines with isocyanides followed by next condensation with aldehydes with presence of TEA. These new BODIPY compounds will be tested by cyclic voltammetry for potential application in organic electronics.
Direction: Science
Event format: Seminar
2019
12 Nov
Kletskov Alexey «Mixed 1,2-azole heterocycles in homogeneous and heterogeneous catalysis in aqueous media»
As a result of joint researches, methods for the synthesis of mixed heterocyclic ligands containing heterocycles completely different in electronic properties (for example, 1,2-azole-1,2,3-triazole, 1,2-azole-pyridine, 1,2-azole-pyrimidine) and their complexes with palladium and nickel were obtained. Palladium isoxazole-1,2,3-triazole complexes are such active catalysts for cross-coupling and reduction reactions in aqueous media that they can be used in trace amounts (1–10 ppm). For the first time, a promising and very active in catalysis of cross-coupling and reduction reactions hybrid bimetallic material based on Pd-Ni-B-L doped with palladium and modified with azole ligands [L - isoxazole-1,2,3-triazole(pyrimide) ligands] was developed.
Direction: Science
Event format: Seminar
2019
15 Oct
Scientific seminar of post-doc Gaddam Krishna «First Total Synthesis of Furanocembranoid-1»
Isolation and medicinal importance: In 2007, Khanitha Pudhom et al. isolated a class of furanocembranoids1 1 (Figure 1) from the hexane extract of croton oblengifolius roxb sp. Furanocembranoids-1 showed cytotoxicities againest BT474 (human breast ductol carcinoma), CHAGO (human undifferentiate lung carcinoma), Hep-G2 (human liver hepatoblastoma), KATO-3 (human gastric carcinoma) and SW-6 (human colon adrenocarcinoma).
Direction: Science
Event format: Seminar
2019
10 Oct
Scientific seminar of post-doc Kletskov A.V. « Novel small macrocycles on the basis of bis-furfurylsulfamides»
The constant growth of interest in different macrocycles can be mainly explained by their broad scope of possible applications. Macrocycles were proven to be valuable bioactive substances and complexing agents.
Direction: Science
Event format: Seminar
2019
8 Oct
Scientific seminar of post-doc Efimov I.V. «Novel and convenient route toward 2,4-disubstituted pyrroles based on the reaction of enaminones and isocyanides»
Pyrrole core is the basis of many pharmacologically active compounds1,2. For example, 3-substituted pyrroles are found in a variety of medicinal and agrochemical applications, such as efficient inhibitors of histone deacetylase3, HIV-1 transcriptase4, and COX-1/COX-2 cyclooxygenases5. Furthermore, the 4-acetyl pyrroles (JWH series) has moderate affinity for the CB1 receptor6.
Direction: Science
Event format: Seminar
2019
3 Oct
Scientific seminar of post-doc S. Cherukupalli «Design and synthesis of novel pyrrole analogues from imidazolines as anticancer agents»
Heterocycles hold a key point in organic and medicinal chemistry as they act as a bridge between life sciences and biochemical investigations. A significant amount of contemporary investigation is being currently pursued on these compounds worldwide.
Direction: Science
Event format: Seminar
2019
17 Sep
Efimov Ilia «1,3-Dipolar cycloaddition of -metalated isocyanides to enamines and enaminones: direct and convenient approach to 1H-2,4-disubstituted pyrroles»
A novel synthetic strategy based on 1,3-dipolar cycloaddition of a-metalated isocyanides to double bond of different enamines and enaminones represent a direct, simple and effective approach to 2,4-substituted pyrroles from common and commercial available starting materials. We found that potassium tert-butoxide is a unique base which can be used for this type of cycloaddition. The new pyrroles were formed in good-to-excellent yields.
Direction: Science
Event format: Seminar
2019
17 Sep
Efimov Ilia «1,3-Dipolar cycloaddition of а-metalated isocyanides to enamines and enaminones: direct and convenient approach to 1H-2,4-disubstituted pyrroles»
A novel synthetic strategy based on 1,3-dipolar cycloaddition of a-metalated isocyanides to double bond of different enamines and enaminones represent a direct, simple and effective approach to 2,4-substituted pyrroles from common and commercial available starting materials. We found that potassium tert-butoxide is a unique base which can be used for this type of cycloaddition. The new pyrroles were formed in good-to-excellent yields.
Direction: Science
Event format: Seminar
2019
17 Sep
Scientific seminar of post-doc Chand H. R. «New methodology for the synthesis of 1H-pyrrolo[1,2-a]imidazole»
The heterocyclic pyrollidine rings are very common in natural products and are the leading components of alkaloids.(1) They are important synthetic components of HIV reverse transcriptase enzyme and inhibitors of substance P neurotransmitters.(2,3)
Direction: Science
Event format: Seminar