Najoua Sbei «A facile one pot synthesis of 1,2,3,4-tetrahydroisoquinoline-1-carbonitrile via the electrogenerated acetonitrile»
The nitrogen heterocycle presents a very important use in the pharmaceutical and agrochemicals synthesis. In this case the substituted tetrahydroisoquinoline has a broad range of biologicals activities.
Iliy Efimov «Novel and convenient route toward 2,4-disubstituted pyrroles based on the reaction of enaminones and isocyanides»
Pyrrole core is the basis of many pharmacologically active compounds. For example, 3-substituted pyrroles are found in a variety of medicinal and agrochemical applications, such as efficient inhibitors of histone deacetylase, HIV-1 transcriptase, and COX-1/COX-2 cyclooxygenases. Furthermore, the 4-acetyl pyrroles (JWH series) has moderate affinity for the CB1 receptor. Besides a wide range of applications in medicinal chemistry pyrroles are also found to be electronically polarizable and oxidizable building blocks for polymeric and supramolecular structures for applications in nonlinear optics.