Najoua Sbei «A facile one pot synthesis of 1,2,3,4-tetrahydroisoquinoline-1-carbonitrile via the electrogenerated acetonitrile»

Najoua Sbei «A facile one pot synthesis of 1,2,3,4-tetrahydroisoquinoline-1-carbonitrile via the electrogenerated acetonitrile»

The event passed
27 Jun 2019
Location
Moscow, Ordzhonikidze St., 3
Contact person
Elena I. Knyazeva
About the event

The nitrogen heterocycle presents a very important use in the pharmaceutical and agrochemicals synthesis. In this case the substituted tetrahydroisoquinoline has a broad range of biologicals activities.

The synthetic study of 1,2,3,4-tetrahydroisoquinoline-1-carbonitrile was reported in different condition by using the cyanopotassium (KCN) with 2-methyl-3,4-dihydroisoquinolin-2-ium iodide in acetonitrile.4,5 In this work our approach is focused mainly on developing new and safe strategy for the conversion of 3,4-dihydroisoquinolin-2-ium iodide substrates into these highly valuable 1,2,3,4-tetrahydroisoquinoline-1-carbonitrile derivatives that proceeds through a process with good yield and is promoted by a high current efficiency EGB. 

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