A novel synthetic strategy based on 1,3-dipolar cycloaddition of a-metalated isocyanides to double bond of different enamines and enaminones represent a direct, simple and effective approach to 2,4-substituted pyrroles from common and commercial available starting materials. We found that potassium tert-butoxide is a unique base which can be used for this type of cycloaddition. The new pyrroles were formed in good-to-excellent yields.